MCB 150 1st Edition Lecture 7 Outline of Last Lecture I. Enzymesa. Endergonicb. ExergonicII. Activation energyIII. Irreversible inhibitorsOutline of Current LectureIV. Competitive InhibitionV. Allosteric InhibitionVI. Nucleic AcidVII. Properties of nucleic acidCurrent LectureCompetitive inhibition: An inhibitor molecule that is physically similar to the substrate and occupies the active site, preventing the catalysis of the substrate. - Enzyme can’t use inhibitor as substrate because no products form. - Can be overcome by flooding the solution with substrate to overwhelm the enzymes- Decreasing the __________ also reduces the probability of inhibitor finding and active siteExamples of competitive inhibitors: - Ethanol is a competitive inhibitor of alcohol dehydrogenaseo Keeps methanol from being broken down into formaldehyde and formic acidThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.Allosteric inhibition: the inhibitor molecule binds to the enzyme in a place other than the active site- If change in enzyme completely prevents substrate binding, increasing substrate concentration has no effect- Reversible because inhibitor can be unboundNucleic Acid:- Two types: Deoxyribonucleic acid and Ribonucleic Acid- Serve an information storage role in a cell- The monomers of Nucleic Acids are: nucleotidesNumbering:Nucleoside monophosphate: Nucleoside + 1 phosphateNucleoside diphosphate: Nucleoside + 2 Phosphates =Nucleoside triphosphate: Nucleoside + 3 Phosphates =Properties of DNA:- Deoxyribose sugar- Pyrimidine bases are Cyosine ( C) and Thymine (T)- Purine bases Adenine (A) and Guanine (G)- Monomers of DNA are called deoxyribonucleotides- They are usually double strandedNucleic Acid Properties- Ribose - Pyrimidine bases are Cytosine (C) and Uracil ( U)- 2 Purine bases: Adenine (A) and Guanine (G) - Monomers of RNA are called ribonucleotides- Normally single