MCB 150 1st Edition Lecture 7 Outline of Last Lecture I Enzymes a Endergonic b Exergonic II Activation energy III Irreversible inhibitors Outline of Current Lecture IV Competitive Inhibition V Allosteric Inhibition VI Nucleic Acid VII Properties of nucleic acid Current Lecture Competitive inhibition An inhibitor molecule that is physically similar to the substrate and occupies the active site preventing the catalysis of the substrate Enzyme can t use inhibitor as substrate because no products form Can be overcome by flooding the solution with substrate to overwhelm the enzymes Decreasing the also reduces the probability of inhibitor finding and active site Examples of competitive inhibitors Ethanol is a competitive inhibitor of alcohol dehydrogenase o Keeps methanol from being broken down into formaldehyde and formic acid These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute Allosteric inhibition the inhibitor molecule binds to the enzyme in a place other than the active site If change in enzyme completely prevents substrate binding increasing substrate concentration has no effect Reversible because inhibitor can be unbound Nucleic Acid Two types Deoxyribonucleic acid and Ribonucleic Acid Serve an information storage role in a cell The monomers of Nucleic Acids are nucleotides Numbering Nucleoside monophosphate Nucleoside 1 phosphate Nucleoside diphosphate Nucleoside 2 Phosphates Nucleoside triphosphate Nucleoside 3 Phosphates Properties of DNA Deoxyribose sugar Pyrimidine bases are Cyosine C and Thymine T Purine bases Adenine A and Guanine G Monomers of DNA are called deoxyribonucleotides They are usually double stranded Nucleic Acid Properties Ribose Pyrimidine bases are Cytosine C and Uracil U 2 Purine bases Adenine A and Guanine G Monomers of RNA are called ribonucleotides Normally single stranded