Be proactive instead of reactive regarding exams groups of cell is this all we are if we take away every single cells in the body would we just disappear NO we will look almost like usual because we have component outside the cell but still part of you extracellular matrix Extra in addition to outside the cells construction via broblast connective cell not muscle not neuron not interacting with environment but create support component for the other cells 1 meshwork of brous proteins Protein also key component in our cell and also outside of cells Fibrous long thin component ex hair is brous brous protein long thin protein different from most protein which is sort of bundled up to each other in globule 3 that we see in our matrix A Collagen ropes Tie two things together like rope they can move relative to each other but can t move away form each other taut want all cell to go together Like train cars collagen injection shot injection that people get for face to support structure component Collagen shot we are adding extracellular matrix The most common protein between organism B Elastin elastics rubberband but Sometimes we want to allow them to get a little bit further apart but then we want them to come back together When go further add force remove force come back when people get collagen injection they get a bit of elastin too for elastity but elastin sounds arti cial like plastic kind of thing C Fibronectin connectors To make sure we can tie everything as necessary to this matrix of brous protein if we take all cells we can at least see this connective component In building if we take away all furniture in the inside can see the building because of the structure inside the structure is not in the room but in between 2 Not only protein component but we know there is uid Viscous water more viscous like syrup water less viscous like uid uid between cells with carbohydrate sugar structures within this area provide support ex paracrine bmove in the uid in between 2 cells 2 support from protein and sugar components Purpose 1 Structure bio glue make sure cell does not slide out 2 In uences cells We have certain cells in our body that are less associated with the matrix and others that are highly associated with the matrix ex RBC not moving around in the blood don t see the matrix in blood component other than uid Cells need this connection with this extracellular matrix The matrix itself exert in uences over those cells that are connected to it so much so if we take a cell normally associated with the matrix from your body and separate them from the matrix isolate it really becomes unhappy go to a process where they commit suicide and die Cell needs the connection with the extracellular matrix to help stabilize its existence and keep them around ensure proper growth of those cells A survival component Typical cell kept away form matrix cell die needs to be associated with the matrix to stay alive B Growth Being associated with the matrix help set up how many cells we can have in a particular area expansion of cells what will it become dictated by the matrix component C Differentiation we saw in 4 groups of primary cell types The extracellular matrix help set up hey you need to go to another path to become muscle cells or to become neuron Fluid compartments water in our body Dominant component of our body is water molecule Ingest water where we will nd it 3 Compartments 1 intracellular uid ICF Cells bags of water water inside your cell within cells cytosol cytoplasm also organelles in there what is inside the cell bet majority of water in body here biggest compartment 67 or 28 L 2 there is uid outside of cells to do indirect communication Extracellular uid ECF blood and uid between the cells 2 extracellular uid component 2 Interstitial uid IF inter between intercellular communication communication between cells interstitial space space between the cell Paracrine neurotransmitter move between IF uid between cells Between cells 26 or 11 L 3 Plasma get a vial of blood and separate cell component on top uid plasma last uid compartment Least likely to nd water because it is the smallest compartment circulator system water portion of blood smallest one only about 7 or 3L Fluid compartment Barriers 3 distinctly different areas slightly different composition similar but not identical only happen when we have barrier divider Between Intracellular uid and Interstitial uid Interstitial uid and the plasma Our stronger barrier between inside the cell and outside the cell or between interstitial uid and plasma Inside the cell to outside the cell because there is bigger differences between the two areas 1 Cellular plasma membrane What that barrier is that is so good to create this very distinctly different composition in our uid compartment that is our cellular plasma membrane create these bags of water that is our cell that allow us to keep eye level of certain things inside and outside our cells 2 Blood vessel walls more speci cally when we re looking that the exchange happening with our blood vessels and our smallest vessel called the capillaries this moving form one compartment to the other happens at our capillary walls Now we have this barrier how do we get the main and how do we things from one thing to another Ingest water can be in any of these 3 compartment but need to pass barrier to do that We need to understand some basics how we put things together Chemistry basics Ions Na 2 Cl electrons don t like to be single alone on match com try to nd a boyfriend They gain and gave away their electron To get extra electron become negative release electron become plus positive Ions have a charge can either gain or give electron aka electrolytes ions ad to buy 2 categories of ions 1 cations net positive ex Na 2 anions net negative Free radicals Have a single electron in outer orbit Not an atom but compound Electrons don t like to be single want to add more electron to solve problem Free radicals grab electron from others Removes electron from another Oxidation process If this is a compound that does the oxidation we called it oxidant We drink things that said antioxidant Antioxidant drink Free radicals are bad they get into our body to do bad things and we ingest thing to get rid of them said the beverages we can t ingest them but we also produce free radicals Our levels vary 1 Ingestion 2 Production Our body produce free radicals NOT ACCIDENT that happens in few spaces but we actually have
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