Wake Tech BIO 112 - Gene Expression Activity

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Part 1:Transcription and TranslationMutationsPart 2:Name: _____Stella Mabiala___________________Gene Expression and MutationsPart 1: Fill in the blanks and answer the questions. Be sure to give detailed responses!Transcription and Translation1. Transcription uses _DNA_____ as a template to make ___mRNA_______.2. Transcription occurs in the _____nucleus____________ of Eukaryotic cells.3. Translation occurs in the _____cytoplasm__________ of Eukaryotic cells. 4. Translation produces _____protein_____________. 5. _____ribosomes_______________ are protein making factories.6. What is a codon?a three-base sequence in mRNA, codes for a specific amino acid. Mutations1. The 3 types of point mutations are- Replacement- Insertion- Deletion 2. Point mutations change ___one___ base in the DNA sequence.3. What is a chromosomal aberration?- Changes to the overall organization of the genes on a chromosome4. What are some of the major causes of mutations?- Some are chemically induced, some are spontaneous, some are radiation induced. 5. What are some of the possible results of mutations?- Possible mutation that benefits the organism.- A mutation that neither hurts nor harms the organism.- A negative mutation that does not benefit the organism.Name: _____Stella Mabiala___________________Part 2: Compare the mutated strands of DNA to the original template DNA in number one.1. Template DNA sequence with no mutations: TAC GCA CCG TAT CAT GAT AATa. Transcribe the DNA to make an mRNA molecule. Write the correct sequenceof bases below:ATG CGT GGC ATA GTA CTA TTAb. Translate the mRNA to make a strand of amino acids (a protein). Use the table of codons found at the end of the assignment to help you. List the amino acids in order below:UAC GCA CCG UAU CAU GAU AAU2. The following strand of DNA has a mutation.TAC CCA CCG TAT CAT GAT AATa. Transcribe the DNA to make an mRNA molecule. Write the correct sequenceof bases below:ATG GGC ATA GTA CTA TTAb. Translate the mRNA to make a strand of amino acids (a protein). Use the table of codons on page 191 in your textbook to help you. List the amino acidsin order below:UAC CCG UAU CAU GAU AAUc. Compare this strand of DNA to the DNA in number 1. What type of mutation isthis? (Be specific- list all mutation types that apply).TAC GCA CCG TAT CAT GAT AAT TAC CCA CCG TAT CAT GAT AATThis is a point mutation, specifically a nucleotide substitution.d. How did the mutation change the amino acid sequence?The base grouping and the sequence of the genes after the substitution will be thrown off. 3. The following mutation occurred to the sequence in #1: TAC GCA CCG TAT ATG ATA ATa. Transcribe the DNA to make an mRNA molecule. Write the correct sequenceof bases below:Name: _____Stella Mabiala___________________ATG CGT ATA TAC TAT TAb. Translate the mRNA to make a strand of amino acids (a protein). Use the table of codons on page 191 in your textbook to help you. List the amino acids in order below:UAC GCA UAU AUG AUA UAc. Compare this strand of DNA to the DNA in number 1. What type of mutation isthis? (Be specific- list all mutation types that apply).TAC GCA CCG TAT CAT GAT AAT TAC GCA CCG TAT ATG ATA ATThis is a point mutation, specifically a nucleotide deletion. d. How did the mutation change the amino acid sequence?The mutation harmfully alters the sequence of the amino


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Wake Tech BIO 112 - Gene Expression Activity

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