New version page

UNC-Chapel Hill BIOC 108 - Lab 05

Documents in this Course
Unit 3

Unit 3

12 pages

Unit 2

Unit 2

16 pages

Unit 1

Unit 1

11 pages

7.1

7.1

11 pages

6.1

6.1

6 pages

4.1

4.1

3 pages

Load more
Upgrade to remove ads
Upgrade to remove ads
Unformatted text preview:

Lab 05: Dietary Lipids in Health and Disease Aspirin for prevention/therapy of heart attacks:» Cyclooxygenases (COX 1 & 2) initiate synthesis of many eicosanoids invarious tissues» In platelets (cells in blood stream involved with clotting): the COX-1 activity gives TXA2o This promotes clotting, this is good so we don’t bleed to death after a small cut» In endothelial cells (blood vessel wall): COX-2 activity gives PGI2o Clotting is inhibited, this is good so clots don’t form and block blood flow » So, we want these 2 processes to be balanced » Aspirin may be prescribed to block both COX-1 and COX-2 (covalent bond, suicide inhibitor) » The endothelial cells have DNA, so they can make more COX-2 and overcome the block from aspirin » However, the platelets do not have a nucleus (no DNA), so no more COX-1 enzyme is made » So … balance shifted to less clotting and less chance of heart attackVegetable (seed) oils in the diet gives us lots of omega 6!o Example: arachidonic acid (20:4beta6) o When it is cleaved, it is converted into eicosanoidso In platelets it is made into TXA2 = platelet aggregationo In endothelial cells it is made into PGI2 = inhibits platelet aggregationSo: aspirin shifts balance towards less platelet aggregation, less clotting, less heart attacks Omega-3 analogs of arachidonic acid (fish oils, flaxseed) produce eicosanoidcousins that are better (less inflammatory, less pro-aggregating, less vasoconstrictive) Animal fats and tropical oils are high in saturated fatsVegetable oils are high in unsaturated fatsOmega 3 fatty acids are high in cold water fish oils and flaxseed


View Full Document
Download Lab 05
Our administrator received your request to download this document. We will send you the file to your email shortly.
Loading Unlocking...
Login

Join to view Lab 05 and access 3M+ class-specific study document.

or
We will never post anything without your permission.
Don't have an account?
Sign Up

Join to view Lab 05 2 2 and access 3M+ class-specific study document.

or

By creating an account you agree to our Privacy Policy and Terms Of Use

Already a member?