UW MICROM 445 - Micro445-2018-02 Notes (46 pages)

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Micro445-2018-02 Notes



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Micro445-2018-02 Notes

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Pages:
46
School:
University of Washington, Seattle
Course:
Microm 445 - Medical Virology
Medical Virology Documents

Unformatted text preview:

Microbiology 445 Medical Virology Viral Replication Spread Pathogenesis Jason Smith Ph D jgsmith2 uw edu Review Session for Exam 1 Friday April 6 4 30 5 30 PM HSB T625 Email one of us if you would like to meet individually at other times Virus Replication and Spread Spread within populations and transmission between hosts Entry into and spread within host Replication within host cells Virus Transmission Anthroponoses humans are the only host Zoonoses disease acquired from animals Direct Transmission Indirect Transmission Human Human Vector Vector Human Human Animal Animal Vector Vector Animal Human Animal Human Direct Transmission Horizontal Saliva Mucus Influenza Fecal matter Poliovirus Blood HIV Semen Genital Secretions HIV Zika Urine Hantavirus Mucosal surfaces Herpes Simplex Skin HPV Fomites inanimate objects that can spread virus by touch door knobs etc Direct Transmission Vertical Virus must cross placenta to infect fetus Virus in birth canal or in blood Virus present in milk Transmission Zoonoses Humans can be infected with certain viruses from animals Human viruses are most likely the result of a past zoonosis and adaptation of the virus to human as the only host Many of the most severe viral diseases rabies Ebola etc are zoonotic Transmission from animals to humans can be direct or indirect Zoonotic diseases are much more difficult to eradicate Indirect Transmission Vectors Vectors are living organisms that can transmit infectious diseases between humans or from animals to humans Mosquitoes are common vectors since they take blood from the host Culex Aedes aegypti Aedes albopictus Ticks can also be vectors for viruses Other bloodsucking animals can be vectors for bacteria and parasites Transmission Amplifying Host In some cases there is an intermediate amplifying host between the natural reservoir and humans Venezuelan equine encephalitis virus Humans can be a dead end host if they do not subsequently transmit the virus either directly or indirectly Go et



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