UW MICROM 445 - Micro445-2018-01 Introduction (60 pages)

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Micro445-2018-01 Introduction



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Micro445-2018-01 Introduction

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Pages:
60
School:
University of Washington, Seattle
Course:
Microm 445 - Medical Virology
Medical Virology Documents
Unformatted text preview:

Medical Virology Microbiology 445 Tuesday and Thursday 1 00 2 20 p m T 625 Professors Jason Smith Ph D course director jgsmith2 uw edu HSB J 279A Michael Lagunoff Ph D lagunoff uw edu HSB J 287 Jennifer Hyde Ph D jlhyde4 uw edu HSB J 257A Microbiology Undergraduate Awards Microbiology Majors Only Deadline for all is April 6th For applications contact Denise Anderson bugsda uw edu Forms also attached to Lecture 1 event in Canvas Bassett Chiller and Evans Awards Criteria for selection include academic merit commitment to a scientific or professional career and financial need Students from diverse backgrounds are encouraged to apply Research Awards David Kingsbury Scholarship Undergraduate Research Awards 3 or 4 per year Interdisciplinary Summer Research Award Ordal Award separate announcement mid quarter Education Award Website Canvas https canvas uw edu courses 11338 99 Please print lecture notes and bring to class attached to events in Canvas Recordings of lectures will be uploaded Exam material is from lectures and notes Reference textbook Human Virology 4th or 5th edition Collier and Oxford Good for pre reading before lecture Administrative Notes Andrea Pardo is your contact for add codes and registration issues acroz uw edu K357A http microbiology washington edu about staff Disability Resources for Students Please be proactive in notifying us of accommodations I have already submitted the alternative testing agreement You are responsible for scheduling exams on time according to DRS rules Administrative Notes Review sessions office hours Review sessions on Fridays 4 30 PM in T 625 April 6 May 4 June 1 Optional but not recorded Contact us by email to schedule office hours Final Exam Currently scheduled for 2 30 pm on Friday June 8 We are petitioning to move to Tuesday June 5 at 10 30 am confirmation will be announced in class and online It will overlap with finals for T R classes that start at 8 00 am or 8 30 am We will resolve conflicts after the second midterm once this is confirmed Exams First midterm 40 points Lectures 1 4 Second midterm 80 points Lectures 511 Final 80 points Lectures 12 18 not comprehensive In class short answer and multiple choice questions Course Overview Introductory lectures Overview taxonomy and structure Replication and spread Immunology vaccines viral diagnosis and epidemiology Viruses that cause acute infections Respiratory viruses Ocular infections viral diseases of the eye Enteric viruses viruses infecting the gut Hepatitis viruses viruses infecting the liver Zoonotic infections viruses spread to humans by animals Viruses that cause persistent or chronic infections or diseases Persistent viruses viruses that you do not clear Oncogenic viruses viruses that can cause cancer Vertical transmission viruses spread from mother to fetus Retroviruses and HIV Other topics Viruses feared for bio terror Viral gene therapy Study Guide We are not testing the history of virology don t memorize dates On occasion we will tell you specific parts of lectures that we are not testing Take notes on what we say during the lectures not everything is spelled out on the slides We will post practice exam questions as the midterms approach Study Guide Specific concepts mode of spread animal bite vertical transmission etc site of replication and disease e g enteric or respiratory persistent vs lytic etc For each major virus discussed you should know Viral Pathogenesis What diseases does the virus cause and how Viral Spread How do people get infected and how does it spread through the body Epidemiology What populations get infected and when When do infected individuals spread the infection Diagnosis How do we determine if people are infected Viral Prevention and treatment Vaccines and drugs used Immune response Basics of viral replication How does the virus replicate and in what cells Viral family and classification What is the discipline of Virology Virology is the study of viruses Basic or Molecular Virology Micro 450 Research into the inner workings of viruses including Replication Viral protein function Viral alterations of host cells and proteins Basic virology combines molecular biology cell biology biochemistry immunology and other disciplines Medical Virology Disease association Pathogenesis Diagnosis Treatment Epidemiology and spread Prevention What is a virus The word virus is derived from the Latin word for poison Originally used to describe all transmissible disease it was changed to filterable virus when filters were found to separate bacteria A virus is not actually a living organism Defining characteristics of viruses Obligate intracellular parasite Genome is either RNA or DNA not both The nucleic acid is enclosed in a protein coat Viruses themselves do not have energy metabolism Viruses require host cell protein synthesis to make progeny virus particles Viruses do not grow or divide they are assembled Thus viruses are not living organisms Viruses have evolved with humans and all other living organisms and been a major part of human history Egyptian stone tablet from ca 1500 BC depicting a man with a withered leg and dropped foot indicative of polio virus infection Egyptian mummy with pockmarked cheeks indicative of smallpox Ramses V 12th c BC Viruses have played a role in history Mayans and other native Americans had never been exposed to smallpox chicken pox or measles When Europeans came to the new world these diseases devastated the native people There are stories of giving pox infested blankets to native Americans to help defeat them The first bio terrorists The Louisiana purchase from the French may have been made because Napoleon s troops were decimated by yellow fever Yellow fever contributed to Panama canal construction by US and not French Major biological discoveries stemming from virology DNA as genetic element came from bacteriophage studies DNA replication worked out in viruses RNA splicing discovered in adenovirus Eukaryotic gene regulation first studied in viruses Recombinant DNA revolution Oncology cancer causing oncogenes first discovered in viruses and these were used to find human protooncogenes Much of modern molecular biology was first learned in viruses Brief History of Eukaryotic Virology 1892 Ivanovsky Agent smaller than bacteria caused tobacco mosaic disease 1898 Beijerinck Infectious agent of tobacco mosaic disease was sub bacterial called it contagium vivum fluidum and showed that virus would propagate in host cells but not sap


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