PGY452/552—Spring 2013 -- EndocrinologySlide 2Navigating PresentationsWant to ask questions after class?Slide 5Key to symbolsTextbook:Exam 1 & how to do well on itStill more testingSlide 10One more timeDr. Michael MoralesOffice: 202 Cary HallHours: by appointmentOffice Phone: 829-3965E-mail: [email protected] you have questions, please E-mail me and put: PGY452 questionin the subject line, so that I’ll be sure to noticePGY452/552—Spring 2013 -- EndocrinologyOffice hours are by appointmentGood questions will be posted on the PGY452 endocrine blog1Tips for Printing:Although I use a lot of color an animation, these slides can be printed using a black & white laser printer. For best results: 1. I intended for you to use the “Handout View” at two slides per page in portrait orientation. If you choose 4 or 6 slides, the text may be too small to read2. On the bottom of the print menu, select Color or Grayscale. Selecting Pure Black & White gives results that are difficult to read.Color or Gray ScalePure B & W2Navigating PresentationsHandouts are not meant to be a text book; if you don’t listen to the lectures & take notes, they will not make senseLook out for icons at the bottom of the screenNotes: Material for which you’ll be responsible (will be on next page)Definitions for which you are responsible (will be at the end)Hints & Tips: Just filling in a few blanks (also at the end)Heavily animated slide3Want to ask questions after class?A good time to find meI happy to answer them outside in the lobby4Good questions will be posted to the UBLearns course blog which is not up yet5Key to symbolsActivity change → protein kinaseActivity change → protein kinase activity activitycomplex stimuli± ± Change enzyme levels by regulation of gene expressionChange enzyme levels by regulation of gene expressionSubstrateProductSubstrateProductSubstrateProduct6TransportPathway (multiple reactions)Single reactionTextbook:You are not directly responsible for material in the text.It might help to read itDefinitionsBasic anatomyEspecially reproductive endocrinologyPlease take a look at Chapters 1-3. If this material does not look familiar to you, please study it carefullyI’m assuming you know it7https://www.clinicalkey.comExam 1 & how to do well on itA study guide will be postedDoes not replace LecturesNotesUnderstanding the materialPrevious questions from the last two yearsThat’s everything; deleted the bad, not representative, & repetitiveTest emphasis might not be the sameIf the only thing you study is last year’s test, you are probably in big trouble(Now that I have your attention)8Still more testingUnless I say otherwise, you will not be expected to memorizeAbbreviations (ACTH=adrenocorticotropin); the exam will include a tableDetails of structuresDetails of synthetic pathways**Some exceptionsHowever, you should have enough familiarity with the above so that I can refer to them in a question without you going into shockYou will understand when you see the practice testThe best students are able to take information from several topics and combine it into new informationSee the big picture9PRELIMINARY LECTURE SCHEDULE# Topic Date Chapt.1 Hormones 1/31 1-3, 372 Endocrine signaling 1/31 3, 373 Regulation of the endocrine system 2/2 404 Complex inputs and the central nervous system 2/2 405 Quick overview of whole body metabolism 2/7 386Short term metabolic control by insulin & glucagon2/7 387 Regulation of long-term energy stores 2/9 388 Diabetes & the Metabolic Syndrome 2/9 389Growth hormone and IGF1: the other face of anabolism2/14 4010 Thyroid hormone 2/16 4111 Cortisol & the slow stress response 2/16 4212 Epinephrine & the fast stress response 2/21 4213 Endocrine regulation of ECF osmolarity 2/21 4214 Calcium homeostasis 2/21 3915Male reproductive endocrinology & fetal differentiation2/23 4316 Female reproductive endocrinology 2/23 4317 Lactation 2/28 43Exam 1 review session 2/28Exam 1Thursday, March 2Exam 1 will cover topics 1-14Exam 1 will cover topics 1-14The fnal will cover 1-4, plus 15-17 The fnal will cover 1-4, plus 15-17 10One more timeOne more timeExam 1Topics 1-4 Topics 5-14 → Exam 1 ONLYProperties of hormones in Topics 15-17 See the study guide & practice testREVIEW session on 2/23 is informalYou ask questionsI answer questions FinalTopics 15-17: ~11 questionsTopics 1-4: ~6 questionsLate in the semester, I will give you a study guide for the fnalThe test questionsYes, the actual test questionsNot the