NMJ poisons/drugsAch antagonists- antagonize Ach binding… “blockers”…curaraeAch antagonists continuedInhibition of Ach exocytosis at NMJPowerPoint PresentationBotulinum toxin continuedSlide 7Slide 8Slide 913-1NMJ poisons/drugsAch agonists- mimic Achetc.wikipediawikipediaNicotine- a drugthat binds and activatesnicotinic receptors13-2Ach antagonists- antagonize Ach binding… “blockers”…curaraecuraraewikipediawikipediahttp://www.rsc.org/Education/EiC/issues/2008september/DeadlyThingsComeInSmallPackages.asphttp://www.rsc.org/Education/EiC/issues/2008september/DeadlyThingsComeInSmallPackages.asp13-3Ach antagonists continuedWeaponize for huntingUsed medicinally as auxiliary Relaxant during anesthesiahttp://www.rsc.org/Education/EiC/issues/2008september/DeadlyThingsComeInSmallPackages.asp13-4Inhibition of Ach exocytosis at NMJBotulinum toxin-prevents Ach exocytosiswikipediawikipedia13-5Botulinum toxin mechanism http://samvednacerebralpalsy.blogspot.com13-6Botulinum toxin continuedDeadly toxin via eating contaminated foodAnticonvulsant and cosmetictreatmentwikipedia http://www.web-libre.orgBotox ®http://www.dallascosmeticcenter.com13-7Acetylchoinesterase inhibitors continued-the badwikipediaSarinA very toxic nerve agent commonlyKnown as “nerve gas”Production is against internationallawwikipedia13-8Nneostigmine- a medicine for Myasthenia gravisAcetylchoinesterase inhibitors continued-the goodwikipediaptosiswikipedia13-9Pathology and treatment of myasthenia gravisInhibition of Ach breakdown allows Ach to build up and out competethe ab from binding allowing some recovery of synaptic