BCOR 103 1st Edition Lecture 14 Outline of Last Lecture I Sorting of Proteins II Uptake of Materials in the Plasma Membrane Outline of Current Lecture I Cell Adhesion Molecules II Cell Cell Junctions III Collagen Current Lecture There are five important cell adhesion molecules Selectins are the first and they combine with carbohydrates This type of cell adhesion molecule is seen mostly in the cardiovascular system and does not form stable cell junctions Integrins are used in cell to matrix interactions and occasionally by immune cells Integrins do form stable cell junctions The third molecule called 4 spanning connects cells in the synapse and forms tight and gap junctions Ig CAMs have 100 different varieties and are important in the immune system as well as neurons Last is Cadherins Cadherins require calcium to make a cell to cell adhesion These are important in tissue differentiation and tissue development Cell to Cell Junctions Name Function Tight Junction Seals two cells together in an epithelial sheet to prevent leakage Adherens Junction Joins an actin bundle in one cell to an actin bundle in a different cell Desmosome Junction Spot Weld that anchors the tough IF s in one cell to another Gap Junction Cell to cell junction allowing the passage of small molecules Hemi desmosome Junction Anchors IF s in a cell to the basal lamina These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute The most common protein in the mammalian body is collagen Collagen is made up of a triple helix of alpha chains It can be constructed of homopolymers or heteropolymers There are three families of collagen fibrillary collagens sheet formin collagens and connecting collagens
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