Psy 200 1st Edition Lecture 11 Current Lecture Amnesia Amnesia is a description of memory Loss of memory that impacts all senses Anterograde partial or total loss of memory for events after neurological disturbance Retrograde loss of memory for events prior to neurological disturbance Retrograde All memories are not lost but more severe retrograde amnesia occurs with systemic diseases like Alzheimer s Anterograde Loss of memory for events that have occurred since the neurological disturbance think of it as a learning deficit Medial Temporal Lobe Hippocampus Amygdala and surrounding cortex e g hypoxia herpes encephalitis Anterograde amnesia shows no primacy effect Recency effect in tact primacy effect gone no encoding benefit Shift focus from localizing specific memories to focus on the study of memory processes Emphasized that storage of memory could be distinct from formation of memory Later work laid groundwork for studies of implicit memory Learning without awareness learn things but do not remember learning them Summary of Hippocampal Amnesia Normal Short Term Memory poor Long Term Memory Affects declarative memory without impairing non declarative memory Mainly anterograde amnesia Some graded retrograde amnesia Dissociation of Declarative and Non Declarative Memory Do declarative and non declarative memories result from operation of different systems Or is there a single system and damage to this disrupts more difficult task of accessing information explicitly These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute This is a single dissociation problem Hippocampal and Memory Acquisition Medial temporal lobe region hippocampus associated with acquisition of declarative memory descriptive amount Consolidation theory hippocampus is part of network for developing associations between representations in different cortical areas A process model Consolidation is the process by which memories are strengthened and stabilized increasing resistance to interference and decay Consolidation is an active process Consolidation alters the memory representation Synaptic Consolidation Long Term Potentiation LTP Systems Consolidation Those that fire together wire together Consolidation Theory of MTL and Memory Acquisition Hippocampus is part of network for developing associates between representations in different cortical areas Accounts for role of MTL region in acquisition of new declarative memories dissociation of retrograde and anterograde amnesia Consolidation occurs in our sleep Sleep and Declarative Memory Sleep increases recall of paired associates There is no significant change in performance after an equal interval of wakefulness Implicit memory also improves with sleep Sleep deprived patients did more poorly on a recognition test Get a good nights sleep