BCHM 4116 1st Edition Lecture 2Outline of Last Lecture I. The Central DogmaII. RNA WorldOutline of Current Lecture I. Comparison of DNA & RNA II. Keto-enolTautomeric ShiftsCurrent LectureI. DNA vs. RNAa. Pyrimidine : Cytosine, Thymine,Uracil (Uracil replaces Thymine in RNA)i. One ring ii. 6-membered aromatic ringb. Purine : Adenine, Guaninei. Two ringsii. 5-membered imidazole ring fused with pyrimidine c. N-glycosidicbond : links base to sugar in DNA & RNAd. Nucleoside = sugar + basee. Nucleotide = phosphate + sugar + basef. Phosphodiesterbond : links a nucleotide to another nucleotide II. Keto-enoltautomeric shift a. To quantify DNA/RNA use bases because bases are aromatic and have a strong absorption at 260 nm b. Keto : C= OThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute. DNA RNABases: A C G T Bases: A C G U3’ hydroxyl group 2’ hydroxyl groupGenetic information Genetic information mRNA, tRNA, rRNA, snRNAc. Enol : C – OH , C =
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