UNT BIOL 4220 - Final Exam Study Guide (4 pages)

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Final Exam Study Guide

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Final Exam Study Guide


Covering lectures 28-38 for BIOL 4220 Exam 3.

Study Guide
University of North Texas
Biol 4220 - Neuropsychopharm
Neuropsychopharm Documents

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BIOL 4220 1st Edition Exam 3 Study Guide Lectures 28 38 Lecture 28 November 3 One of the therapeutic uses for amphetamine is for narcolepsy and ADHD attention deficit hyperactivity disorder Uses for ephedrine is anti asthmatic agent The signal that triggers the vesicular release of neurotransmitter when action potential arrives at the axon terminal is Ca2 calcium ion entry into the axon terminal When amphetamine binds to dopamine transporters it reverses the effect of the dopamine transporter The exchange diffusion model of amphetamine action on the pre synaptic axon terminal is facilitating vesicular release of dopamine The reverse transporter model of amphetamine action is when the transporter flips into an inside out configuration pumping dopamine out instead of pumping it in Lecture 29 November 5 There are experiments used to prove that release of dopamine induced by amphetamine is not coming from vesicular release The transport of dopamine into the synaptic vesicle by VMAT is dependent on activation of the dopamine transporter The function of VMAT is to pump monoamines such as dopamine into synaptic vesicles One of the sympathomimetric effects is heightened alertness vigilance and motor activation If a person is overdose on amphetamine the subtype of amphetamine induced psychosis catatonic schizophrenia Lecture 30 November 7 Characteristic behavioral effects of amphetamine include heightened alertness increase in selfconfidence feeling of exhilaration decrease in boredom and decreased sleep A characteristic effect of high dosage of amphetamine is stereotypic purposeless pacing and paranoia Serotonin is degraded by the enzyme monoamine oxidase Dopamine is slowed down by end product inhibition when dopamine accumulates in the cytoplasm Amphetamine is trapped inside the synaptic vesicles because it is ionized once inside the vesicles Lecture 31 November 10 Characteristics of ADHD include hyperactivity inattention impulsivity and hyperkinesias ADDRT residual type

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