IOHMeORNHRNOOMeHPd(0)1 Provide a mechanism2. Predict the product. Explain your choicePd(0)Et3NBrDHHHDDHH3. Reaction of 1 with mCPBA gives intermediate 2. Subsequent reaction with NaCN gives 3. What is the structure of 2. Explain your reasoning based on what you know about epoxide opening reactions.HHOHmCPBA12NaCNHHOH1CNOHChem 634, PS2, 2006, Prof Fox4. The amination reaction of chloride 1 with amine 2 is faster than the corresonding reaction with bromide 3. However, when equimolar amounts of 1, 2 and 3 are combined, adduct 5 is the major product. Explain how this is possible.ClNHO12Pd(0)P(tBu)2(just a ligand)NaOtBuNO4reaction completein 1 h at 80°CBrNHO32Pd(0)P(tBu)2NaOtBuNO5only 29% conversion after 1 h at 80 °CbutClNHO12Br3Pd(0)P(tBu)2NaOtBuNO597%NO43%1 equiv1 equiv 1 equiv80 °C5 h5. Reading assignment from the Primary Literatureprovide a brief synopsis (hand drawn structures) of a paper from the primary chemical literature.!ˇ Organic Letters and Tetrahedron Letters are the most appropriate sources for papers. Select an article that describes a new type of synthetic methodology.! In addition to outlining the main idea of the paper, I ask that you make a list at the bottom of "reactions/concepts learned by reading this
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