U of M
CHEM 2301 -
Electrophilic Addition to Alkenes
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Electrophilic Addition to AlkenesGeneral Scheme:++E = electrophilic groupX = leaving groupExample: Hydrohalogenation (addition of HX).++Markovnikov’s Rule of Electrophilic AdditiAdditionElectrophiles typically add such that the most stable pypycation intermediate is formed. (Usually, so that the electrophile is bound to the less substituted carbon.)Hydrohalogenation example:+selectively.not observed.We would call this reaction regioselective.Markovnikov Addition of H2O to AlkenesHydrationH2SO4/H2OHarsh and reversible.regioselectively.not
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