BIO 304 -- Principles of Genetics (Summer 2006, 7/7-8/3) Lecture: MTWRF 10:20-12:20 PM 116 T.H. Morgan Bldg. Recitation: TR 12:40-4:00 PM 116 T.H. Morgan Bldg. Instructor: John Rawls 316 Morgan Bldg. 257-4647 [email protected] Office Hours: MW 1-3:00 P.M. Required Text: Introduction to Genetic Analysis, 8th edition, by Griffiths, Wessler, Lewontin, Gelbart, Suzuki & Miller, W.H. Freeman Co., NY, 2005 (includes CD and extensive WWW site aides) Recommended: Solutions Manual for Introduction to Genetic Analysis, by W. Fixen & D. Lavett, W.H. Freeman Co., NY 2005 Molecular Biology of the Cell, by Alberts et al. or any modern cell biology text. WWW: http://www.uky.edu/~jrawls/bio304/ Prerequisites: BIO 150-153; BIO 315 Objectives: This course should provide you with the basic knowledge and skills to understand and apply the principles of modern genetics. You should gain an understanding of the important fundamental concepts of genetics as they pertain to Mendelian principles, linkage analysis, the nature of genes, regulation of development, and dynamics of populations. Because of the broad scope of the material in the course, specific areas cannot be covered in detail. Rather, the goal will be to provide you with the necessary tools to approach the solution of genetic problems. By the end of the course, you should be able to make hypotheses about such genetic problems, design experiments to test those hypotheses, and interpret the experimental results. It is expected that this course will be appropriate preparation for advanced coursework in genetics, professional school, graduate school, or other careers in biology. BIO 304 fulfills a requirement in genetics for the Biology major and for certain other majors. Expectations: As a core course for Biology majors, BIO 304 is a challenging course and will require strong academic effort. Many students find genetics to be a particularly difficult subject, in large part because it is a highly inferential subject. Especially in a four-week summer format, where we will be covering about one text chapter each day, students must be prepared to give very strong effort outside of class each day. To do well, one must master a basic array of genetics principles, thendiligently practice applying those principles in solving problems. In BIO 304 you will be responsible for materials presented in lecture, in text readings, and in recitation exercises. The text is the framework for this course and will serve as a detailed reference. It is strongly recommended that you read the assigned chapters before lecture. The lectures will emphasize the material that is particularly important (and likely to appear on exams). Lectures will also include material that is not specifically covered in the text, but will be on the exams. Finally, because much of genetics is based on problem solving, expect to see problems on the exams. The best models for exam questions are the problem sets in the text, the accompanying CD and the publishers WWW site. If you keep up with the problem sets, and seek help for problems you do not understand, you are likely to do well in the course. Grading: Grades will be determined by scores on the three examinations (75%; each exam is weighed equally) and by scores from recitation (25%). The third exam will not be a comprehensive final, but a regular exam. Both the second and third exams will expect use of basic tools and information covered earlier in the course. The following traditional letter grade system will be used: A = 90-100 B = 80-89 C = 70-79 D = 60-69 E = <60 Absolute grades may be scaled up depending on the overall distribution of scores, but in no case will grades be lower than this scale. Makeups for exams or other graded assignments will be allowed only in cases of excused absences (see University Bulletin for definitions). Makeup exams will be scheduled as needed. You will be excused from a graded recitation assignment only if you have a permissible excuse, and you must contact the instructor regarding making up work done in that meeting. Recitation: Recitation is intended to reinforce the material covered in lecture and the text, and provide an opportunity for students to ask questions about the assigned problems. Each lecture, a set of problems from the text will be assigned and due at the next recitation meeting. While the solutions to these problems are in the Solutions Manual, it is to your benefit to try to work them out on your own. Plagiarized answers are unacceptable. Some recitation meetings will also include exercises designed to give you more "hands on" and interactive experience. Graded assignments may accompany those exercises. Your recitation grade will be based on the scores you receive on the problem sets.Schedule Text pages July 7 Patterns of Inheritance 27-72 10 Chromosomal Basis of Inheritance 73-114 11 (R) Eukaryotic Chromosome Recombination Mapping 115-150 12 Genetics of Bacteria and Their Viruses 151-184 13 (R) From Gene to Phenotype 185-226 14 EXAMINATION I 1-184 17 DNA: Structure and Replication 227-254 18 (R) RNA: Transcription and Processing 255-272 19 Proteins and Their Synthesis 273-300 20 (R) Regulation of Gene Transcription 301-340 21 Gene Isolation and Manipulation 341-388 24 Genomics 389-422 25 (R) Transposable Elements 423-450 26 EXAMINATION II 185-422 27 (R) Mutation, Repair and Recombination 451-480 28 Large-scale Chromosomal Changes 481-520 31 Dissection of Gene Function 521-544 Normal and Cancer Cells 558-574 August 1 (R) Genetic Basis of Development 575-511 2 Population Genetics 611-642 Evolutionary Genetics 679-706 3 EXAMINATION III 423-706 On Examination days, one hour will be devoted to the exam and the remainder of the class meeting will be devoted to lecture. (R) Denotes recitation