UK BIO 304 - Lecture 8 (18 pages)

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Lecture 8



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Lecture 8

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Pages:
18
School:
University of Kentucky
Course:
Bio 304 - Principles of Genetics

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Chapter 9 Proteins and their synthesis Compartmented Coupled transcription translation transcription processing translation Fig 9 1 oteins are polymers of amino acids joined through peptide bond Each protein has a amino and a carboxyl terminus Fig 9 2 he function of a protein is dependent upon its overall tructure each level of protein structure is dependent pon lower levels thus all are derivatives of primary tructure of the polypeptide he primary structures of polypeptides are directly erived from the primary structures of their mRNAs rimary structures of mRNA are derived from the rimary structures of their DNA templates splicing hanges in DNA sequence can alter function of protein ncoded by that DNA sequence Protein higher order structures amino acid sequence Regular coil sheet motifs stabilized by H bonds between peptidyl atoms specific intramolecular folding stabilized by associations of amino acid R groups Fig 9 3 intermolecular associations stabilized by associations of amino acid R groups Fig 9 4 Genes encode the primary structure of proteins E coli trpA mutations genetic map is co linear with the protein C Yanofsky Fig 9 5 Fig 9 8 Degeneracy in the codon amino acid code derives from Multiple codons for certain same amino acids e g UCU UCC UCA UCG UGU UGC serine tRNAs convert the codon amino acid code mediated by aminoacyl synthetases Fig 9 10 Degeneracy in the codon amino acid code derives from Multiple codons for certain same amino acids e g UCU UCC UCA UCG UGU UGC serine Wobble permits certain individual tRNAs to pair with multiple codons Wobble creates partial ambiguity in codon 3 nucleotides Fig 9 12 Three significant domains of ribosome during translation A incoming aminoacyl tRNA binding site P peptidyl tRNA binding site E exiting deacylated tRNA site Fig 9 15 Three phases of translation Initiation association of small subunit and capped 5 end of mRNA association of Met tRNA fMet scanning to AUG eukaryotes association of large subunit Fig 9 18 Three



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