Biomedical Glycobiology Frontier of N glycan study 1 Alpha mannosidase II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis Chui D Oh Eda M Liao YF Panneerselvam K Lal A Marek KW Freeze HH Moremen KW Fukuda MN Marth JD Cell 1997 Jul 11 90 1 157 67 2 Genetic remodeling of protein glycosylation in vivo induces autoimmune disease Chui D Sellakumar G Green R Sutton Smith M McQuistan T Marek K Morris H Dell A Marth JD Proc Natl Acad Sci U S A 2001 Jan 30 98 3 1142 7 3 Mammalian N glycan branching protects against innate immune selfrecognition and inflammation in autoimmune disease pathogenesis Green RS Stone EL Tenno M Lehtonen E Farquhar MG Marth JD Immunity 2007 Aug 27 2 308 20 Function of Mannosidase II in N glycan Biosynthesis Cell 1997 Generation of Mannosidase II Knockout Mice Cell 1997 Mannosidase II Enzyme Activity Cell 1997 The Mannosidase II Knockout Mice Develop Dyserythropoietic Anemia Anisocytosis a patient s red blood cells are of unequal size Little i antigen poly Nacetyllactosamine Large I antigen poly Nacetyllactosamine 1 6 GlcNAc branch Cell 1997 The Mannosidase II Erythrocytes Lack Complex N glycans Lectin E PHA Cell 1997 The Mannosidase II Deficiency Reduces Complex Increases Hybrid N glycans PNAS 2001 The Mannosidase II Mice Develop Glomerulonephritis Kidney Liver PNAS 2001 The Hematopoietic and Immune Parameters in the Mannosidase II Mice PNAS 2001 Presence of Autoantibodies in the Mannosidase II Mice PNAS 2001 Nonhematopoietic Origin of Autoimmune Disease in M II Deficiency Immunity 2007 Disease in the Absence of Adaptive Immune System and IgG Treatment RAG 1 is essential to the generation of mature B and T lymphocytes two cell types that are crucial components of the adaptive immune system Immunity 2007 Pathogenesis in the Absence of Complement C3 macrophage C3 plays a central role in the complement system and contributes to innate immunity Immunity 2007 Innate Immune Activation and Kidney inflammation Immunity 2007 Mesangial Cell Activation and Apoptosis Immunity 2007 Mesangial Cell Activation and Apoptosis Immunity 2007 Mesangial Cell Activation and Apoptosis Immunity 2007 Self Glycan Triggers an Innate Immune Response in Mice Lacking mannosidase II Immunity Preview 2007 Have a Fun Summer Evaluation Forms
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