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anatomy
study of the structure of living organisms
physiology
study of the function of living organisms
gross (macroscopic) anatomy
the study of large body structures visible to the naked eye
regional anatomy
a subdivision of gross anatomy; studies all the structures in a particular region of the body at the same time
systemic anatomy
a subdivision of gross anatomy; body structure is studied system by system
surface anatomy
a subdivision of gross anatomy; the study of internal structures as they relate to the overlying skin surface
microscopic anatomy
deals with structures too small too be seen with the naked eye
cytology
studies the cells of the body
histology
studies the tissues of the body
developmental anatomy
traces structural changes that occur in the body throughout the life span
embryology
a subdivision of developmental anatomy; concerns developmental changes that occur before birth
renal physiology
concerns kidney function and urine production
neurophysiology
explains the workings of the nervous system
cardiovascular physiology
examines the operation of the heart and blood vessels
principle of complementarity of structure and function
what a structure can do depends on its specific form; function always reflects structure
chemical level
the simplest level of the structural hierarchy of the human body; studies atoms combining to form molecules, molecules forming organelles, and cells.
cellular level
the second level of the structural hierarchy of the human body; studies the smallest units of living things
tissue level
the third level of the structural hierarchy of the human body; studies groups of similar cells that have a common function
organ level
the fourth level of the structural hierarchy of the human body; studies discrete structures composed of at least two tissue types that perform a specific function for the body
organ system level
the fifth level of the structural hierarchy of the human body; studies organs that work together to accomplish a common purpose
organismal level
the highest level of the structural hierarchy of the human body; represents the sum total of all structural levels working together
necessary life functions
maintain boundaries, move, respond to environmental changes, take in and digest nutrients, carry out metabolism, dispose of wastes, reproduce, and grow
maintain its boundaries
separating a living organism's internal environment from the external environment surrounding it
movement
includes the activities promoted by the muscular system
contractility
on the cellular level, the muscle cell's ability to move by shortening
responsiveness (excitability)
the ability to sense changes (which serve as stimuli) in the environment and then respond to them
digestion
the breaking down of ingested foodstuffs to simple molecules that can be absorbed into the blood
metabolism
a broad term that includes all chemical reactions that occur within body cells
excretion
the process of removing wastes, or excreta, from the body
reproduction
occurs at the cellular and organismal level; dividing the original cell to produce two identical daughter cells or uniting a sperm with an egg
growth
an increase in size of a body part or the organism as a whole; usually accomplished by increasing the number of cells
survival needs
nutrients, oxygen, water, appropriate temperature, and appropriate atmospheric pressure
nutrients
taken in via the diet; contain the chemical substances used for energy and cell building
oxygen
necessary for all the nutrients in the world to be useful
water
accounts for 60-80% of our body weight and is the sing most abundant chemical substance in the body
normal body temperature
must be maintained for chemical reactions to continue at life-sustaining rates; about 98.6 degrees F
atmospheric pressure
the force that air exerts on the surface of the body
homeostasis
the body's ability to maintain relatively stable internal conditions even though the outside world changes continuously
variable
the factor or event being regulate
receptor
some type of sensor that monitors the environment and responds to changes called stimuli by sending information (input) to the control center along the afferent pathway
control center
determines the set point, which is the level or range at which a variable is to be maintained, as well as analyzes the input it receives and determines the appropriate response or course of action. information (output) then flows from the control center to the effector along the efferent …
effector
provides the means for the control center's response (output) to the stimulus
negative feedback mechanism
the output shuts off he original effect of the stimulus or reduces its intensity; most homeostatic control mechanisms
positive feedback mechanisms
the result or response enhances the original stimulus so that the response is accelerated
homeostatic imbalance
when the body's internal environmental variable become disturbed
anatomical position
the anatomical reference point
directional terms
allow us to explain where one body structure is in relation to another
axial part
makes up the main axis of our body; includes the head, neck, and trunk
appendicular part
consists of the appendages, or limbs, which are attached to the body's axis
regional terms
used to designate specific areas within these major body divisions
sagittal plane
a vertical plane that divides the body into right and left parts
median (midsaggital) plane
a sagittal plane that lies exactly in the midline
parasagittal plane
all other sagittal planes offset from the midline
frontal (coronal) plane
a vertical plane that divides the body into anterior and posterior parts
transverse (horizontal) plane
a horizontal plane that divides the body into superior and inferior parts
cross section
a transverse section
oblique sections
cuts made diagonally between the horizontal and the vertical planes
dorsal body cavity
protects the fragile nervous system organs; subdivides into the cranial cavity and the vertebral or spinal cavity
cranial cavity
in the skull, encases the brain
vertebral (spinal) cavity
runs within the body vertebral column, encloses the delicate spinal cord
ventral body cavity
the more anterior and arger of the closed body cavities; subdivides into the thoracic cavity and the abdominopelvic cavity. houses viscera
viscera
internal organs, collectively
thoracic cavity
surrounded by the ribs and muscles of the chest; subdivides into lateral pleural cavities and the medial mediastinum
pleural cavities
each enveloping a lung
mediastinum
contains the pericardial cavity
pericardial cavity
encloses the heart, and surrounds the remaining thoracic organs (esophagus, trachea, etc.)
abdominopelvic cavity
separated from the superior thoracic cavity by the diaphragm; subdivides into the abdominal cavity and the pelvic cavity
abdominal cavity
contains the stomach, intestines, spleen, liver, etc
pelvic cavity
lies in the bony pelvis and contains the urinary bladder, some reproductive organs, and the rectum
serous membrane (serosa)
a thin, double-layered membrane that lines the walls of the ventral body cavity and the outer surfaces of the organs it contains
parietal serosa
the part of the membrane lining the cavity walls
visceral serosa
the part of the membrane covering the organs in the cavity
serous fluid
a thin layer of lubricating fluid that separates the serous membranes
demosomes
anchoring junctions; mechanical couplings scattered like rivets along the sides of abutting cells to prevent their separation
cells
the structural units of all living things
cell theory
a cell is the basic structural and functional unit of living organisms the activity of an organism depends on both the individual and the collective activities of its cells
generalized (composite) cell
any one of a collection of different types of cells that all have the same general chemical makeup that perform the same functions
the three parts of the human cell
plasma membrane: outer boundary cytoplasm: intracellular fluid packed with organelles nucleus: an organelle that controls cellular
plasma membrane
defines the extent of a cell, thereby separating two of the body's major fluid compartments--the intracelluar fluid within cells and the extracellular fluid outside cells
fluid mosaic model
depicts the plasma membrane as an exceedingly thing structure composed of a double layer, or bilayer, of lipid molecules with protein molecules dispersed in it
phospholipids
lollipop-shaped molecules with a hydophilic head and hydrophobic tail
hydophilic
water loving
hydrophobic
water fearing
glycolipids
lipids with attached sugar groups; found only on the outer plasma membrane surface
integral proteins
proteins firmly inserted into the lipid bilayer
peripheral proteins
proteins not embedded in the ipid bilayer; they attach loosely to integral proteins and are easily removed without disrupting the membrane
lipid rafts
dynamic assemblies or saturated phospholipids associated with unique lipids called sphingolipids and lots of cholesterol
glycocalyx
a layer of externally facing glycoproteins on a cell's plasma membrane; its components determine blood type and are involved in the cellular interactions of fertilization, ebryonic development, and immunity, and act as an adhesive between cells
tight juction
area where plasma membranes of adjacent cells are tightly bound together, forming an impermeable barrier
gap junction
a passageway between two adjacent cells; formed by transmembrane proteins called connexons
interstitial fluid
extracellular fluid; fluid between the cells
selectively (differentially) permeable
allows some substances to pass while excluding others
passive processes
substances cross the membrane without any energy input from the cell
active processes
the cell provides the metabolic energy (usually ATP) needed to move substances across the membrane
types of passive transport
diffusion and filtration
diffusion
the tendency of melcules or ions to move from an area where they are in higher concentration to an area where they are in lower concentrations, that is, down or along their concentration gradient
concentration gradient
the difference in the concentration of a particular substance between two different areas
simple diffusion
nonpolar and lipid-soluble substances diffuse directly through the lipid bilayer (e.g., oxygen, carbon dioxide)
facilitated diffusion
movement through the membrane by a passive transport process in which the transported substance either (1) binds to protein carriers in the membrane and is ferried across or (2) moves through water-filled protein channers
carriers
transmembrane integral proteins that are specific for transporting certain polar molecules or classes of molecules, like sugars or amino acids, that are too large to pass through membrane channels
channels
transmembrane proteins that transport substances, usually ions or water, through aqueous channels from one side of the membrane to the other
osmosis
the diffusion of a solvent, such as water, through a selectively permeable membrane from a dilute solution into a more concentrated one
aquaporins (AQPs)
transmembrane proteins that form water channels
osmolarity
the total concentration of all solute particles in a solution
hydrostatic pressure
the back pressure exerted by water against the membrane; pressure of fluid in a system
osmotic pressure
a measure of the tendency of water to move into a more concentrated solution
tonicity
the ability of a solution to change the shape or tone of cells by altering the cells' internal water volume
isotonic solutions
have the same concentrations of nonpenetrating solutes as those found in cells; cells exposed to this retain their normal shape
hypertonic solutions
have a higher concentration of nonpenetrating solutes than seen in the cell; cells immersed in this lose water and shrink
hypotonic solutions
are more dilute (contain a lower concentration of nonpenetrating solutes) than cells; cells places in this plump up rapidly
active transport
membrane transport processes for which ATP is required; requires carrier proteins that combine specifically and reversibly with the transported substances
solute pumps
move solutes, most importantly ions, "uphill" against a concentration gradient; cells must expend energy to do this
symport system
a type of secondary active transport; the two transported substances move in the same direction
antiport system
a type of secondary active transport; the transported substances cross the membrane in opposite directions
primary active transport
a type of active transport in which the energy needed to drive the transport process is provided directly by hydrolysis of ATP
sodium-potassium pump
a primary active transport system that simultaneously drives sodium out of the cell against a steep gradient and pumps potassium back in
electrochemical gradients
the combined difference in concentration and charge; influences the distribution and direction of diffusion of ions
secondary active transport
transport driven indirectly by energy stored in ionic gradients created by primary active transport pumps
vesicular transport
fluids containing large particles and macromolecules are transported across cellular membranes inside membranous sacs called vesicles
clathrin
the coating found on the cytoplasmic face of the pit of the enfolding portion of the plasma membrance; bristlelike protein
phagocytosis
the cell engulfs some relatively large or solid material
phagosome
vesicle formed as a result of phagocytosis
amoeboid motion
the flowing movement of the cytoplasm of a phagocyte
pinocytosis
a bit of infolding plasma membrane surrounds a very small volume of extracellular fluid containing dissolved molecules
receptor-mediated endocytosis
the type of endocytosis in which engulfed particles attach to receptors before endocytosis occurs
caveolae
tubular or flask-shaped inpocketings of the plasma membrane
exocytosis
vesicular transport processes that eject substances from the cell interior into the extracellular fluid
membrane potential
voltage across the plasma membrane
resting membrane potential
the voltage that exists across the plasma membrane during the resting state of an excitable cell; ranges from -90 to -20 millivolts depending on cell type
polarized
state of a plasma membrane of an unstimulated neuron or muscle cell in which the inside of the cell is relatively negative in comparison to the outside; the resting state
membrane receptors
a huge and diverse group of integral proteins and glycoproteins that serve as binding sites
cell adhesion molecules (CAMs)
found on almost every cell in the body; play key roles in emryonic development, wound repair and immunity
ligands
chemicals that bind specifically to plasma membrane receptors; most neurotransmitters, hormones, and paracrines)
g protein-linked receptors
exert their effect indirectly through a g protein
g protein
a regulatory molecule that acts as a middleman or relay to activate (or inactivate) a membrane-bound enzyme or ion channel
second messengers
intracellular molecule generated by the binding of a chemical (hormone, neurotransmitter) to a receptor protein; mediates intracellular responses to the chemical messenger
cyclic AMP
intracellular second messenger that mediates the effects of the first (extracellular) messenger (hormone, neurotransmitter), formed from ATP by a plasma membrane enzyme
cytoplasm
the cellular material between the plasma membrane and the nucleus; the site of most cellular activities; consists of three parts: the cytosol, organelles, and inclusions
cytosol
the viscous, semitransparent fluid in which the other cytoplasmic elements are suspended
organelles
the metabolic machinery of the cell; each carries out a specific function for the cell
inclusions
chemical substances that may or may not be present, depending on cell type (e.g., nutrients)
mitochondria
threadlike or lozenge-shaped membranous organelles; the power plants of a cell, providing most of its ATP supply
cristae
inner membrane folds
ribosomes
small, dark-staining granules composed of proteins and a variety of RNAs called ribosomal RNAs; sites of protein synthesis
endomembrane system
a system of organelles that work together mainly to (1) produce, degrade, store, and export biological molecules, and (2) degrade potentially harmful substances; includes the ER, golgi apparatus, secretory vesicles, and lysosomes
cytoskeletom
an elaborate network of rods running through the cytosol and hundreds of accessory proteins that link these rods to other cell structures; supports cellular structures and provides the machinery to generate various cell movements; the three types are microfilaments, intermediate filaments…
microfilaments
the thinnest elements of the cytoskeleton; semiflexible strands of the protein actin; strengthen cell surface, resist compression, and transmit force during cellular movements and shape changes
intermediate filaments
tough, insoluble protein fibers that resemble woven ropes; made of twisted unit of tetramer (4) fibrils; most stable and permanent of the cytoskeletal elements and have a high tensile strength; act as internal guy-wires to resist pulling forces exerted on the cell
microtubules
hollow tubes made of spherical protein subunits called tublins; radiate from a small region of cytoplasm near the nucleus called the centrosome (cell center); remarkably dynamic, constantly growing, disassembling, and then reassembling at the same or different sites; determine the overall…
motor proteins
tiny protein machines that continually move and reposition the organelles along the microtubules

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