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A Fibers
Average Diameter: 20 micrometers; Average Conduction Velocity: 50 meters/second
B Fibers
Average Diameter: 3 micrometers; Average Conduction Velocity: 3 meters/second
C Fibers
Average Diameter: 1 micrometer; Average Conduction Velocity: 0.5 meters/second; Always unmyelinated
Compound Action Potential
Summation of action potentials from many (hundreds to thousands) axons in a nerve.
Chemical Synapse
Junction that: has vesicles, has transmitters, is not a gap junction, is fatiguable, has synaptic delay, has rectification(one-way transmission), has miniature end-plate potentials, is predominate in vertebrates, is excitatory, is inhibitory.
Electrical Synapse
Junction that: does not have vesicles, does not have transmitters, is a gap junction, is not fatiguable, does not have synaptic delay, does not have rectification(one-way transmission), does not have miniature end-plate potentials, is predominate in invertebrates, is excitatory, is not in…
EPSPs (Excitatory Post-Synaptic Potential)
Potential that results from Sodium or Calcium movement in
IPSPs (Inhibitory Post-Synaptic Potentials)
Potential that results from potassium movement out or chloride movement in.
Slow (Indirect) Chemical Synapse
Chemical synapse with large, often elliptical vesicles; large molecules, such as peptides, for transmitters released further from synaptic cleft; receptors linked to G-proteins and then to channels.
Neuromodulator
A substance released by slow synapses.
Nerve Gas (Sarin or Tabun)
Nerve Gas (Sarin or Tabun)
Neuromodulator
Nerve Gas (Sarin or Tabun)
Nerve Gas (Sarin or Tabun)
Blocks acetylcholinesterase; causes convulsions and spastic paralysis.
Eserine (Physostigmine
Blocks acetylcholinesterase; causes spastic paralysis (at high concentrations).
Curare
Blocks receptor; Causes rapid flaccid paralysis
Botulinum Toxin
Destroys vesicle docking proteins; Causes slowly developing flaccid paralysis and prevents exocytosis
Hemicholinium 3
Blocks choline uptake (slows acetylcholine synthesis); Causes slow flaccid paralysis
Reserpine
Empties vesicles; Causes flaccid paralysis
Carbacol
Binds and opens acetylcholine channels; Causes spasticity.
Myasthenia Gravis
Blocks acetylcholine receptor; Causes slow flaccid paralysis and, ultimately, death.
Bungarotoxin
Binds irreversibly to acetylcholine receptor; Causes rapid flaccid paralysis and, ultimately, death.
Nicotinic Acetylcholine Receptor
Receptor that: responds to acetylcholine and nicotine, is blocked by curare, and is found primarily at striated muscle.
Muscarinic Acetylcholine Receptor
Receptor that: responds to acetylcholine, muscarine and pilocarpine, is blocked by atropine, and is found primarily at the vagus nerve, cardiac muscle, smooth muscles, glands, parasympathetic system.
Acetylcholine
Neurotransmitter that is excitatory at striated muscles and inhibitory at heart nodal tissue.
Glycine
Neurotransmitter that is inhibitory and primarily in spinal cord.
GABA
Neurotransmitter that is inhibitory and is throughout entire nervous system.
Glutamate
Neurotransmitter that is excitatory and is throughout the entire nervous system.

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