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New evidence for protective effects of DHEAS



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Office of Population Research Princeton University WORKING PAPER SERIES New evidence for protective effects of DHEAS on health among men but not women Working Paper No 2006 05 Noreen Goldman Dana A Glei Last Revised July 31 2006 Corresponding author Office of Population Research Princeton University 243 Wallace Hall Princeton NJ 08544 2091 USA E mail ngoldman princeton edu Tel 609 258 5724 Fax 609 258 1039 Department of Demography University of California Berkeley 1512 Pembleton Place Santa Rosa CA 95403 2349 USA Abbreviations DHEA Dehydroepiandrosterone DHEAS Dehydroepiandrosterone sulfate SEBAS Social Environment and Biomarkers of Aging Study CES D Center for Epidemiologic Studies Depression scale Papers published in the OPR Working Paper Series reflect the view of individual authors They may not be cited in other publications but are intended to be work in progress Comments are welcome 1 ABSTRACT The adrenal androgen dehydroepiandrosterone DHEA and its sulfate form DHEAS have been the focus of considerable publicity in recent years because of their demonstrated associations with a broad range of health outcomes Yet despite a large literature examining the health consequences of DHEA S few have been based on prospective surveys of population representative samples Thus our knowledge about the causal effects of DHEA S on health in humans is limited and often inconclusive In this analysis we use a national longitudinal survey in Taiwan to explore the associations between DHEAS and changes over a 3 year period in functional limitations cognitive impairment depressive symptoms and global self rated health for men and women Our estimates suggest that for the older Taiwanese population DHEAS is related to subsequent declines in mobility and increased depressive symptoms among men but there are no significant associations between DHEAS and women s mental and physical health These findings differ from those in a previous cross sectional analysis based on the Taiwan study



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