Mechanisms of Acquired Immunity II

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Mechanisms of Acquired Immunity II

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Lecture Note
University of Southern California
Bisc 307l - General Physiology
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BISC 307L 1st Edition Lecture 32 Current Lecture  Major Histocompatibility Complex o o All cells produce at least one of the MHC molecules o Each nucleated cell is labeled with a large complement of unique molecules o Non nucleated cells don’t have MHC molecules ( red blood cells) Only have 2 glycosurface proteins used for recognition called A and B. Those that don’t have either are O  Classes of MHC Proteins o o Class 1  Expressed in all cells with nuclei  Present antigens to T cells  Cytotoxic T cells and helper T cells will recognize antigens by the antigens binding to the T cell receptors  Has a lot of variability in the antigen binding site  Alpha and beta chains  T cell receptor binds to the antigen but T cell receptors don’t bind to naked antigens like B cells. The T cell receptor must also bind to the MHC class I presenting the antigen and must be stabilized by CD8

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