BIBC 102 – METABOLC BIOCHEM - FINAL RANDY HAMPTONFALL QUARTER 2004 12/09/200421. Complex I:A) gets electrons from NADPHB) generates NADHC) donates electrons to succinateD) produces ubiquinol2. Which respiratory complex is most like one involved in light-dependentreactionsA) IB) IIC) IIID) IV3. An enzymeA) decreases the free energy of a chemical reactionB) lowers the activation energy of a chemical reactionC) alters the equilibrium concentrations for a reactionD) covalently modifies its substrate4. Allosteric activation of liver-specific hexokinaseA) decreases appetiteB) promotes release of glucose into the bloodstreamC) traps free glucose in cellsD) increases tissue consumption of glucose5. Lipoic acidA) will accept electrons and carries an acetyl groupB) will accept electronsC) will carry an acetyl groupD) will covalently react with pyruvate6. When muscles undergo exercise (as when a human is attacked) what is theorder of ATP-replenishing actionsA) phosphocreatine transfer, glycolysis, respirationB) glycolysis, phosphocreatine transfer, fatty acid oxidationC) glycolysis, use of muscle glycogen, respirationD) acylcarnitine, glycolysis, respiration7. PFK-1 allosteric regulation is best described asA) positive regulation by ATP that is inhibited by ADPB) negative regulation by ATPC) negative allosteric regulation by ATP that is releaved by ADPD) positive regulation by ADPBIBC 102 – METABOLC BIOCHEM - FINAL RANDY HAMPTONFALL QUARTER 2004 12/09/200438. Leptin, the substance encoded by the OB locus of mice,A) is released by the gut after a mealB) diminishes the absorption of calories from the gutC) causes adipocytes to consume more fatty acidsD) stimulates activity and suppresses appetite9. Which anapleurotic enzyme consumes phosphoenoylpyruvateA) PEP carboxylaseB) pyruvate kinaseC) PEP kinaseD) pyruvate carboxylase10. Pyridoxylphosphate (PLP)A) is a Krebs cycle interemediateB) is required for decarboxylations (I allowed this answer too, since it is oftentrue, although D is the best answer because that is how it is used in all cases)C) can accept electrons from NADHD) has an aldehyde group that reacts with amine nitrogens11. The pentose phosphate pathwayA) oxidizes glucose at the 6 carbonB) oxidizes glucose at the 1 carbonC) reduces NAD+D) generates PRPP as a product12. Fatty acid synthesis occurs inA) the mitochondrial matrixB) the mitochondrial matrix in mammals and the cytosol in plantsC) the cytosol in mammals and the chloroplast in plantsD) the mitochondrial matrix in mammals and the chloroplast in plants13. Glucose regulates glycogen breakdownA) by stimulating the phosphorylation of glycogen phosphorylaseB) by directly binding to glycogen phosphorylaseC) by allosterically regulating the phosphatase that modifies glycogen phosphorylaseD) by allosterically regulating the kinase that modifies glycogen phosphorylase14. Glutamine synthetase is regulated byA) adenylylation, which is regulated by uridylylationB) phosphorylationC) uridylylation, which is regulated by adenylylationD) transamination, which is regulated by uridylylationBIBC 102 – METABOLC BIOCHEM - FINAL RANDY HAMPTONFALL QUARTER 2004 12/09/2004415. In people, the majority of waste nitrogen generated in muscleA) is carried to the liver in glutamateB) is carried to the liver in glutamineC) is carried to the liver in alanineD) is carried to the liver as urea16. In people, excess nitrogen is excretedA) in glutamineB) in uric acidC) in alanineD) in urea17. The nitrogen atoms in ureaA) both come from carbamoyl phosphateB) come from ammonia and aspartateC) are a source of anabolic nitrogenD) come from ornithine and carbamoylphosphate18. A half cell reaction with an actual E'o of –0.4 volts (a vigilant student pointedout that B would also be true… they're right! both B and C will get credit)A) will run as an oxidation in the presence of a half reaction of less than -0.4 voltsB) will run as a reduction in the presence of a half reaction of less than -0.4 voltsC) will run as an oxidation in the presence of a half reaction greater than -0.4voltsD) will run as an oxidation in all conditions19. HIF-1αA) is released by tumor cells when they are undergoing apoptosisB) causes tumor cells to die when it binds to a receptor on those cellsC) promotes glycolysis and blood vessel formationD) increases cellular enzymes for glycolysis and the Krebs cycle20. Complex IIA) is a Krebs cycle enzymeB) is free in the matrix of the mitochonrionC) removes electrons from succinate by forming NADHD) uses a Q cycle to do redox chemistry21. The pictured moleculeA) is formed during deamination of alanineB) is a substrate of an anapleurotic reactionC) is a pentose phosphate pathway intermediateD) is made in the first reaction of carbon fixationBIBC 102 – METABOLC BIOCHEM - FINAL RANDY HAMPTONFALL QUARTER 2004 12/09/2004522. If the activation energy of a reaction increases by 4kJ/mole, the forward rateA) will be accelerated by a factor of e4/kTB) will be slowed by a factor of 4/kTC) will be slowed by a factor of e4/kTD) will be accelerated by a factor of 4/kT23. Dietary triglyceridesA) have two fatty acyl groups in their structuresB) have proteins and lipids in their structuresC) are broken down in the gut for synthesis of new triglyceridesD) are absorbed in the gut and placed directly in chylomicrons24. The nitrogenase complexA) converts nitrogen into nitrates by oxidationB) converts ammonia into an excretable formC) converts molecular nitrogen to useable ammoniaD) converts nitrates into nitrites for plant absorption25. Citrate lyaseA) is inhibited by statins for lowering blood cholesterolB) generates AcCoA from citrate in the mitochondrial matrixC) appears to be needed for tumor cells to surviveD) generates NADPH in the cytosol26. If enzyme I has a lower Km than enzyme II, then IA) will have a lower maximum velocity than IIB) will have higher maximum velocity than IIC) will be less saturated at a given substrate concentration than IID) will be more saturated at a given substrate concentration than II27. The bacterial flagellumA) converts a proton gradient into rotary motionB) hydrolyses ATP for movement in bacteriaC) has an ancestor on the mitochondrial membraneD) uses a proton gradient to form ATP in bacteria28. Phospholipids are synthesizedA) by the addition of a CDP-bound headgroup to diacylglycerolB) by the addition of a CDP-bound
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