Fall 2006 Metabolic (BIBC 102) Final Randy Hampton 2 1. Substrate level phosphorylation A) is part of the glycolytic phosphoglycerate kinase reaction B) pertains to the action of ATP synthase C) is how an H+ gradient is made across membranes D) is part of the reaction of Fr 1,6 bisphosphatase 2. Thermogenin A) transports protons across the mitochondrial inner membrane B) binds ATP keeping it from halting H2O production C) is found in the outer membrane of mitochondria D) is reduced by electrons in complex IV 3. Which metabolic reaction does not occur in the cytosol A) production of succinyl-Coa from α-ketoglutarate B) phosphorylation of fructose 6-P C) oxidation of glucose6-P by NADP+ D) ATP-dependent cleavage of citrate to generate Ac-CoA 4. You enter a tiny submarine located in the mitochondrial matrix. You fire up the engines and pilot the vessel to the cytosol. What is the most likely order of things to see passing by the porthole during your voyage from the matrix outward. A) outer membrane, intermembrane space, inner membrane, cytosol. B) inner membrane, matrix, outer membrane, cytosol. C) outer membrane, inner membrane, matrix, cytosol. D) inner membrane, intermembrane space, outer membrane, cytosol. 5. Which of the metabolic reactions below is involved in moving electrons across a membrane: A) re-oxidation of cytochrome c by complex IV B) transamination of alpha ketogluarate into glutamate C) transfer of an H- ion from NADH to Complex I D) oxidation of succinate to fumarate 6. CDP-diacylglycerol A) is an intermediate in phospholipids synthesis B) is formed during triglyceride catabolism C) shuttles diacylglycerol across a membrane D) is an intermediate in ketone body formation 7. Gluconeogenesis A) allows conversion of fat into glucose in mammalian cells B) occurs in the mitochondrion C) allows conversion of fat into glucose in plants D) is upregulated by insulinFall 2006 Metabolic (BIBC 102) Final Randy Hampton 3 8. The “Cori cycle”, that describes the flow of molecules to and from muscle during intense activity: A) is a way the body moves nitrogen from muscle to liver B) involves the cyclic degradation of amino acids to urea and carbon skeletons C) includes an alternative to the Krebs cycle that allows acetate to be synthesized into glucose with no loss of carbons D) is a way the body moves carbon from muscle to liver 9. Glycogen's branches A) are made by glycogen synthase B) are made by branching enzyme from UDP-glucose subunits C) are made by branching enzyme from linear chains made during glycogen synthesis D) consist of individual glucose linked together by alpha(1-6) linkages 10. Rubisco A) converts a 5 carbon molecule into a 6 carbon molecule B) uses biotin to add CO2 to its substrate C) converts a 5 carbon molecule into two distinct 3 carbon molecules D) converts a 5 carbon molecule into two identical 3 carbon molecules 11. Debranching enzyme A) rearranges branched glucose chains on glcogen and generates free glucose B) is used to synthesize glycogen that is not branched C) completely hydrolyzes glycogen branches into glucose-1P D) rearranges branched glucose chains on glycogen 12. Citrate lyase inhibitors A) inhibit a reaction of the Krebs cycle B) inhibit the synthesis of only cholesterol C) inhibit the synthesis of cholesterol and fatty acids D) inhibit the synthesis of only fatty acids 13. The enzyme nitrogenase A) converts NOx into usable nitrogen for plants B) is produced by plants to fix elemental N2 into ammonia C) produces NH3 from N2 D) functions both in mammals and plants to convert nitrogen into a useable from 14. Chylomicrons A) are lipoproteins produced by the liver B) deliver dietary fats to the circulation from the gut C) are part of the mitochondrial structure D) are a unit of measurement used in microscopy of organellesFall 2006 Metabolic (BIBC 102) Final Randy Hampton 4 15. In C. elegans, lowering mitochondrial activity A) causes decreases in fat stores B) causes them to eat less food, which makes them live longer C) causes an increase in lifespan D) causes a decrease in lifespan 16. De novo synthesis of the pyrimidine ring A) occurs on a ribose-derived carrier B) occurs on a glucose-derived carrier C) occurs on a nucleotide carrier D) does not occur on a carrier 17. De novo synthesis of the purine ring A) occurs on a ribose-derived carrier B) occurs on a glucose-derived carrier C) occurs on a nucleotide carrier D) does not occur on a carrier 18. The urea cycle A) produces no amino acids that are found in proteins B) removes urea from the amino acid R C) removes urea from the amino acid ornithine D) uses succinate as a source of atoms 19. Phosphoenoylpyruvate carboxykinase A) is an ATP-requiring step in gluconeogenesis B) is an enzyme of glycolysis C) catalyzes the production of PEP D) adds CO2 to OAA using biotin 20. Synthesis of glucose from pyruvate A) requires both GTP and ATP to run spontaneously B) requires energy rich molecules, and is thus not spontaneous C) uses all of the enzymes of glycolyisis D) uses requires two enzymes from the Krebs cycle 21. A sixteen carbon fatty acid (palmitic acid) is being synthesized. An acetyl group with the methyl carbon labeled with 14C is used in the last reaction cycle. All other reactions before and after use unlabeled acetate. Which carbon is labeled in the resulting product molecule? As you know, fatty acids are numbered with the carboxyl group being number 1. A) carbon number 2 B) carbon number 1 C) carbon number 15 D) carbon number 16Fall 2006 Metabolic (BIBC 102) Final Randy Hampton 5 22. When a palmitae is synthesized by the FAS, as in the question above, de novo from acetyl Co A, how many reaction cycles take place to produce the final fatty acid? A) Damned if I know! B) 16 C) 8 D) 7 23. The first reaction of the glyoxylate cycle that distinguishes it from the Krebs cycle is A) cleavage of isocitrate into glyoxylate and succinate B) rearrangement of isocitrate by isocitrate isomerase C) condensation of acetyl-CoA with glyoxylate D) generation of glyoxylate by removal of CO2 from a precursor 24. One of the observations from the tissue-specific insulin receptor
View Full Document
Unlocking...