Slide 1Slide 2Slide 3Slide 4Slide 5Slide 6Slide 7Slide 8Slide 9Slide 10Slide 11Slide 12Slide 13Slide 14Slide 15Slide 16Slide 17Slide 18Slide 19Slide 20Slide 21Slide 22Slide 23Other sugarsSlide 25Slide 26DisaccharidesSlide 28Slide 29Slide 30Lactose + H2O D-galactose + D-glucose Sucrose + H2O D-fructose + D-glucose Trehalose + H2O 2 D-glucoseLactose Intolerance OMIM Online Mendelian Inheritance in ManGalactose to Glucose 1-PSlide 34Slide 35Slide 36Slide 37Slide 38Slide 39Chapter 15 pp. 560-570 (some figures from Chapter 7) in Lehninger 4th ed.Catabolic Pathways Glycogen → Glu-6-P (glycogenolysis) Glu-6-P → Pyruvate (glycolysis) Anabolic Pathways Pyruvate → Glu (gluconeogenesis) Glu → Glycogen (glycogenesis)Slide 423 enzymes of glycogen breakdown (Glycogenolysis)Slide 44BIBC 102Summer 2005Lecture 4August 8, 2005Fig. 13.9FORMATION OF ATP IN LIVING CELLS1. Glycolysis2. Oxidative phosphorylation in mitochondria3. Oxidative phosphorylation in chloroplastsBIOLOGICAL WORK1. Activation of metabolism2. Transport of metabolites in and out of cells3. Biosynthesis of macromolecules: DNA, RNA, protein, polysaccharides4. electrical signaling (nerve cells)5. Motility and force generation6. Regulatory mechanismsChapter 15 in LehningerGlycolysis Catabolism of HexosesV&V 16.5acid-base catalysis in the isomerase reactionV&V 16.6formation of a Schiff base as a covalent intermediatein the aldolase reactionV&V 16.9V&V 16.10LNC 15.7LNC 15.8Hydrolysis ?H2OH2OV&V 16.28THIAMINE PYROPHOSPHATEMetabolic flux and its controlLNC 15.16LNC 15.18aactive siteactive siteregulatory siteregulatory sitePhosphofructokinase 1(only two of four subunits shown)Other sugars•Fructose•Galactose•Mannosepp. 534-537 (Section 14.2) Feeder Pathways for GlycolysisOther Common SugarsMonosaccharides: fructosegalactosemannoseDisaccharides: sucrose Glu-Frulactose Gal-Glumaltose Glu-Glutrehalose Glu-GluFig. 9.12 in LNCDisaccharidesFigure 7-12Galactose GlucoseFigure 7-12GlucoseFructoseFigure 7-12GlucoseGlucoseLNC 15.11Lactose + H2O D-galactose + D-glucoseSucrose + H2O D-fructose + D-glucoseTrehalose + H2O 2 D-glucose LactaseSucraseTrehalasep. 535Enzymes on surface of intestinal epithelial cellsLactose IntoleranceOMIMOnline Mendelian Inheritance in ManGalactose to Glucose 1-PFigure 14-11Figure 14-11p. 565Figure 14-11Figure 14-11, p. 537NADH + H+NAD+Galactose Galactose 1-PUDP-GluUDP-GalGlucose 1-PGlucose 6-PkinaseUridyl transferaseepimerasephosphoglucomutaseATP ADPEnzymes required for galactose metabolismGLYCOGEN METABOLISMLNC Chapter 15GLYCOGEN SYNTHESISLNC Chapter 20Chapter 15 pp. 560-570(some figures from Chapter 7) in Lehninger 4th ed.Glycogen MetabolismCatabolic PathwaysGlycogen → Glu-6-P (glycogenolysis)Glu-6-P → Pyruvate (glycolysis)Anabolic PathwaysPyruvate → Glu (gluconeog en esis)Glu → Glycogen (gl ycog enesis)Figure 7-14b3 enzymes of glycogen breakdown(Glycogenolysis)1) glycogen phosphorylase2) glycogen debranching enzyme3) phosphoglucomutaseEnd of lecture 4, August 8,
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