Cardiovascular System II

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Cardiovascular System II

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Lecture Note
University of Southern California
Bisc 307l - General Physiology
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BISC 307L 1st Edition Lecture 24 Current Lecture Cardiovascular System  Excitation- Contraction Coupling and Relaxation o o A lot like skeletal muscle  There are t tubules- but not quite as extensive  There is also the SR and channels and contractile proteins o 1. Red zone = action potential in the sarcolemma of the fiber (carried by sodium ions and calcium ions o 2. Calcium ions come through voltage gated calcium channels will bind to the ryanodine receptor and open it-not mechanical like it is in skeletal muscle but it is due to calcium ions) o 4. Calcium ions previously sequestered in SR are released. Triggers contraction o 5. More calcium. 90% released from SR and 10% released through plasma membrane through voltage gated channels o 6. Contraction o 8. Calcium pumps resequester calcium o 9. Ca/Na+ antiport moves calcium out as well (unlike skeletal muscle. Sodium is pumped in o 10. The sodium being pumped in is maintained by the sodium potassium pump

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