Thyroid and Growth Hormone 1

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Thyroid and Growth Hormone 1

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University of Southern California
Bisc 307l - General Physiology
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BISC 307L 1st Edition Lecture 17 Current Lecture Glucocorticoids last slide   Stress activated many areas of the brain o Have sympathetic and parasympathetic responses o Epinephrine is rapidly acting and cortisol is slower and more persistent o But they share similar functions o Epinephrine inhibits many of the functions that parasympathetic system would enhance o Neurons activated will use norepi as a transmitter as well as CRH as a transmitter o Norepi neurons mediate appropriate aggressive responses o CRH neurons inhibit appetite and growth and reproduction o *Cross talk between the right hand (endocrine side) and left side (neural side) o Cortisol also has effects on feeding Thyroid Hormone, Growth Hormone  Thyroid Follicles o o Growth of skeleton requires Ca2+ o Thyroid gland is in neck and wraps around in front of larynx. Within the thyroid gland the functional unit is the thyroid follicle:  Spherical organs (sphere of a layer of epithelial cells) filled with colloid  In between the follicles there are C cells and these C cells secrete calcitonin  Yellow stuff is the colloid thus the apical side is downward  Cells secrete protein into the colloid and the protein being secreted is  1. Thyroglobulin – most abundant  rich in tyrosine residues  synthesis happens extracellular in the colloid  2. Iodide ions  Brought in by sodium iodide symporter  Only place in the body where there is known to be a dietary requirement for iodide  Taken against concentration gradient  Transported by pendrin (Cl- and I- ions exchanger)

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