Course Information LS3 Section 2: Introduction to Molecular Biology Instructor: Debra Pires Office Hours: T 11-1 and W 11-1 Schlicter Hall 2877 [email protected], phone 825-0376 Course Website: http://www.lsic.ucla.edu/ Text: Cell and Molecular Biology: Concepts and Experiments by Karp 4th Edition Lectures: TR 9:30-10:45 Moore 100 Lectures will be based on the reading listed in this handout. There will be additional examples given in the class that may not be from the text, but are chosen to help in understanding different concepts in the course. Lectures will be posted on the course website the night before so that you can print them out and bring them to class if you choose. Labs: There are five labs for this course during weeks 2,4,6,9 and 10. Each lab is three hours long. These labs are designed to give you practical experience in molecular biology techniques, and reinforce material you are learning in lecture. Discussion sections: In weeks where there are no labs you will attend discussion section in the assigned rooms. There are four discussion sections during weeks 1,3,5,7 and 8. These discussion sections are approximately 1 ½ hours and attendance is required. Discussion sections are run by your TA’s and are your opportunity to ask questions about material that may seem unclear, or to go over problems that have been assigned to help you study for the exams. Exams and Review Sessions: You have two midterms for the course. Both midterms are held in the evenings, so please plan accordingly. You must take the exams on the scheduled date as there are no make-up exams. Fail to appear, hand in, or take an exam will result in a zero for that exam. There are no exceptions to this policy. Enrollment: All questions related to enrollment should be taken to the LS Core office in the Life Sciences building room 2305. Neither myself nor the Core Office has PTE’s to distribute. Exams and Grading: Material for the exams will be taken from lectures, the text and problems that have been handed out in class. There will be no multiple choice questions on the exams. The exams will cover all material, including the previous days lecture material. Grades are based on a straight scale. All grades will be posted into my.ucla. An answer key will be posted after each exam so that you may compare your answers to the key.Midterm 1: February 1st 5 – 6:50 PM Midterm 2: February 22nd 5 – 6:50 PM Final Exam: March 20th 6:30 – 9:30 Regrading policy: Any request for a regrade must be made within one week of the exam being returned to you. If you think there has been a simple addition error on your exam then write a note explaining which page was added incorrectly, attach this to the front of the exam and turn it into the LS Core office. If think there was an error in grading that is not an addition mistake then write a brief note explaining why you think more points should be awarded, attach this to the front of the exam and turn it into the LS Core office. In the event that you do turn in your exams, you should make a photocopy for your own records. All exam regrades will be done at the end of the quarter after we have calculated final grades. If the points you request will affect your final grade then we will reevaluate the exam to look for grading errors. Point Breakdown: Midterm 1 100 Midterm 2 100 Final Exam 150 Lab 100 Reading Quizzes 60 Participation 50 Total Points 560 Academic Dishonesty: My best advice to you is just don’t do it!!! If you are caught cheating (e.g. giving answers to someone else or receiving answers from someone else, turning in your work that is not in your own words, etc.) on any graded material in the course you will receive a zero as your score. In addition, you will be reported immediately to the Dean of Students – NO EXCEPTIONS – for further action. Reading Quizzes: There will be a quiz administered using Blackboard every Tuesday beginning in Week 3. These quizzes are based on the previous week’s reading. They are only available for a limited time, you must login and take the quiz before it times out. Reading quizzes are open book, and they are designed to help you look over the material and review what we have covered in the previous week.Date Topic Assigned Reading 01/09 Course introduction 01/11 Chemistry Review Ch. 2; 75-77 Ch. 10; 403-410, 428-432 Nucleic Acids 01/16 Genome structure Ch. 10 410-417 01/18 Protein Structure Ch. 2; 51-77 01/23 Enzymes Ch. 3; 95-106 01/25 Protein Analysis Ch. 18; 751-761 01/30 Prokaryotic transcription Ch. 11; 437-443 02/01 Prokaryotic Gene Expression Ch. 11; 472-484 02/06 Prokaryotic trans. Regulation Ch. 12; 517-520 02/08 Eukaryotic transcription Ch. 11; 443-469 02/13 Eukaryotic trans. Regulation Ch. 12; 520-539 02/15 RNA processing 02/20 Eukaryotic translation Ch. 12; 539-545 02/22 DNA replication Ch. 13; 551-570 02/27 DNA replication error and repair Ch. 13; 570-575 03/01 Viruses Ch. 1; 21-25 03/06 Recombinant DNA technology Ch. 18; 761-775 03/08 Libraries, Screening Ch. 18; 775-778 Sequencing, DNA analysis 03/13 Genomics Handout 03/15 The “Bigger”