Figures removed due to copyright reasons. Please see: Fig.2A-D in Top Curr Chem 209 (2000): 1-51.Figure removed due to copyright reasons. Please see Fig. 1 in Current Opinion in Chemical Biology 7 (2003): 285-295.chain length factor (CLF)--> reduces carbonyl to hydroxyllike dehydratasesCYC and ARO very similar --> same type of proteinFigure removed due to copyright reasons. Please see Fig. 44 in Nat Prod Rep 18 (2001): 380-416.KR / reductionchanges way PK folds on itselfFigure removed due to copyright reasons. Please see Fig. 1 in JACS 125 (2003): 12708-12709.self cleavage from the thioester (see novobiocin biosynthesis from NRPS section)KKR --> each KR has own regioselectivity --> timing of KR. --> sometimes before ARO/CYCsometimes acts after ARO/CYCFigure removed due to copyright reasons.Please see Fig. 11 in Top Curr Chem 209 (2000): 1.Figure courtesy of: Tang, Yi, Taek Soon Lee, and Chaitan Khosla. "Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases." PLoS Biology 2, no.2 (2004): 0227-0238.* = 14C (radioisotope)starting material"Primary metabolism"immediate precursorFigure removed due to copyright reasons. Please see Fig. 8 in Nat Prod Rep 18 (2001): 380-416.Content removed due to copyright reasons. Please see: Mann, John. Chemical Aspects of Biosynthesis. New York, NY: Oxford University Press, 1994, pp. 22-23, 26-27.Figure removed due to copyright reasons. Please see Fig. 23 in Nat Prod Rep 18 (2001): 380-416.Figure removed due to copyright reasons.Figure removed due to copyright reasons.Please see Scheme 1 in J Biol Chem 275 (2000): 38393-38401.Please see Scheme 1 in ChemBioChem 4 (2003): 713-715.Figure removed due to copyright reasons.Please see Fig. 6-13 in Nat Prod Rep 18 (2001):
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