UF CHM 6304 - Electrical Properties of Membranes

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Slide 1Slide 2Slide 3Slide 4Slide 5Slide 6Slide 7Slide 8Slide 9Slide 10Electrical Properties of Membranes•Internal Dipole Potential –probably due to the oriented carbonyl of acyl chains•Born Energy – Work to move charges into the bilayer•Membrane Surface Potential –due to charges on the surface•Local pH at Membrane Surfaces•Metal Ion Binding•Probe Binding/Hydrophobic Ions/Cell Penetrating Peptides•Transmembrane Potential – due to ion permeabilities leading to gradients on either side of the bilayer (can also be protein transport driven)•Ions and Protons•Energized Membranes •Permeability to Ions•Transmembrane Potential DiffusersInternal Dipole Potential ~ 240mV positive inside the bilayerNa+Cl-Dielectric constant for water ~ 80Dielectric constant for membrane ~2WB = (81Z2/r) kcal/molBorn model – work required to transfer a charged species from water to the bilayerSurface Potential and Gouy-Chapman Theory•Charges are smeared uniformly over the surface (not individual points)•Ions in solution are treated as point charges•Image effects and repulsions of mobile ions are neglected•Dielectric constants are considered constant in each phase•Stern modification takes into account the size of charges on the surface and maximum number that can bindSurface Potential and Gouy-Chapman TheoryGouy-Chapman TheorypH at charged surfacesTransmembrane PotentialsIonophores - increase membrane permeability to


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UF CHM 6304 - Electrical Properties of Membranes

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