Synaptic Transmission Part III

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Synaptic Transmission Part III

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University of Southern California
Bisc 307l - General Physiology
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BISC 307L 1st Edition Lecture 8 Current Lecture Synaptic Transmission Part 3  Synaptic transmission in the CNS entire surface of the neuron are covered in synapses  o Each input weak  Thus Integration determines overall effect  Excitation and inhibition (predominant are inhibitory) o Different transmitters  Will release different transmitters onto the same neuron  The postsynaptic neuron puts in receptors for different neurotransmitters o Different receptors for each transmitter  On postsynaptic cell  Membrane protein trafficking problem  Each transmitter can have multiple receptors also (glutamate has multiple) o Ionic and metabolic effects  Integration of Excitation and Inhibition o 1. Stimulate Excitatory channel: Increase in permeability of Na+ and permeability of K+  Summing up of synaptic activity  Stimulation is excitatory so depolarizes  Example: AMPA type of glutamate receptor  Opens a channel that is specific for monovalent cations (Na+ and K+) and when this channel opens it lets Na+ and K+ through so their permeability simultaneously increases  Given that it has a normal negative resting potential when the synapse is active, Na+ creates a large driving force for Na+ current in to the cell and not as big of a outward K+ current so there is more Na+ coming in causing depolarization  Where is the critical place where inward current exceeds outward current?

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