PSYC 3303 1nd Edition Lecture 16 Outline of Last Lecture I. NarcoticsA. Harm-reduction approachB. Causes For ConcernC. Physical DependenceD. Psychological DependenceE. TreatmentII. LSD and Other HallucinogensA.ClassifiedB.Serotonin Related (LSD)i.Discovery ii.Usesiii.Acute Effects of LSDiv.Pharmacologyv.Fact and Fictionvi.Psilocybinvii.LAA (Lysergic Acid Amide)C.Norepinephrine Related i.Mescalineii.DOMiii.MDMA (Ecstasy)D.Acetylcholine Relatedi.Amanita MuscariaE.Miscellaneous Hallucinogensi.PCP (Phencyclidine)Outline of Current Lecture III. MarijuanaA. Acute EffectsB. FactsC. Chronic EffectsD. Toxicity potentialCurrent LectureIII. MarijuanaThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.- A plant- Great debate whether to legalize or not- Majority in USA favor legalization- Colorado and Washington can use it recreationallyA. Acute Effects:- Absorption is rapid (seconds)- Peak effects around 10 min- Effects last around 2 hrs- Excretion slow (half-life 50 hrs)- Physiological effects: i. Increased heart rateii. Dilation in vessels in eyes (redness)iii. Increase/decrease/no change in blood pressure- OD potential: safest drug (20000-40000 times effective dose)- Reaction times do not change- No alteration of basic functions (e.g. respiration) because receptors (cb2) it acts on are not in brain stem- Impacts ability to concentrate- High doses – alters memory functionB. Facts:- Primary active ingredient is THC (Most in bud, some in plant, none in stalk)- Processed=Hashish (higher THC)- Hash oil – flows- THC content: i. In the past: 1-8% in Marijuanaii. Now lot more potent: 15-20%iii. Oil: 40-50%- Washington was connected to “hemp” (used for clothes, rope etc.)- Usually inhaled (fastest way to get it to brain- Ways to smoke: i. Jointii. Pipeiii. Water pipe (better, fluid filters it)iv. Can eat it (in butter)v. Usually not I.V.- Can detect in body after 1 week- So could result “Under influence” but actually just detectable - Considered performance enhancing- Possible to result positive with second hand smoke (but takes a lot)C. Chronic Effects:- Increase as dose increase- Dependence: some signs of physical (anxiety, depression etc.). Psyc dependence : can occur (craving, use even if know it’s bad, becoming part of lifestyle?)D. Toxicity Potential:- Maybe only 1 human death (none reported?)- Increased heart rate but not major issue- Panic reactions- Lung probs + carcinogenic (if vaporize/pill – better)- Reproductive effects- Suppressed immune function- No synergetic
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