BIOL 209 1st Edition Lecture 19 Outline of Last Lecture I. Question/Answer’sII. RecombinationA. ConjugationB. TransformationC. TransductionOutline of Current Lecture I. Question/Answer’sII. Acquisition of Drug ResistanceIII. Infectious DiseasesIV. Human Microbiome: our normal microfloraV. Koch’s PostulatesCurrent LectureI. Question/Answer’sA. What gene transfer mechanism doesn’t require recombination between donor and recipient cell DNA for stable inheritance of transferred genes? Conjugation using F factor1. Whole genome conjugation H factor transfer requires recombinationII. Acquisition of Drug ResistanceA. Spontaneous mutations of gene transfer from another species – transformation, transduction, conjugationIII. Infectious DiseasesA. Those caused by infectious agents and those that aren’t1. Communicable v non-communicable2. Infectious v non-infectiousa. Infectious: usually communicable, but not always (Tetanus)B. Pathogen: an organism that makes us sick1. Localized infection, systemic infection, focal infection (local infection with systemic effects), and mixed infections (caused by several pathogens)a. Secondary infection: infection of one site affects the body so that another pathogen takes overIV. Human Microbiome: our normal microfloraA. Microbes have:1. A protective function2. Alternations in growth conditions with fermentation products3. Impacts on our metabolism and development of our immune systemsThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.B. Location: everywhere1. Microbes are NOT found in internal organs or tissues, however2. We all have unique microbiomes a. Developed by age 2 and stable thereafter – can be changed by disease, antibiotics, and changes and diet, howeverV. Koch’s PostulatesA. Determining causative agent of infectious disease1. Find evidence of a particular microbe in every case of disease2. Isolate microbe – grow/characterize in lab3. Inoculate susceptible healthy subject with lab isolate and observe resultant disease4. Re-isolate agent from this
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