VCU HGEN 619 - Univariate Analysis (9 pages)

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Univariate Analysis



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Univariate Analysis

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Pages:
9
School:
Virginia Commonwealth University
Course:
Hgen 619 - Quantitative Genetics
Quantitative Genetics Documents

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Univariate Analysis HGEN619 class 2006 Tests Saturated model n Equality of means n Is m1 m2 Is m1MZ m1DZ m2MZ m2DZ n Equality of variances Is v1 v2 Is v1MZ v1DZ v2MZ v2DZ 1 Equality Tests n Main Script n Last Group Option Multiple Issat End n n n n n n n n Save ozbmisat mxs equate means and variances Equate M 1 1 1 M 1 1 2 M 2 1 1 M 2 1 2 Equate X 1 1 1 X 1 2 2 X 2 1 1 X 2 2 2 End Specific Equality Tests n n n n n n n n n n n n n n n Get ozbmisat mxs equate means within zygosity groups Equate M 1 1 1 M 1 1 2 Equate M 2 1 1 M 2 1 2 End equate means across zygosity groups Equate M 1 1 1 M 1 1 2 M 2 1 1 M 2 1 2 End equate variances within zygosity groups Equate X 1 1 1 X 1 2 2 Equate X 2 1 1 X 2 2 2 End equate variances across zygosity groups Equate X 1 1 1 X 1 2 2 X 2 1 1 X 2 2 2 End 2 Multiple Fit MZ group 1 Full DZ group 2 par m1 m2 v1 cov v2 m3 m4 v3 cov v4 1 2 3 4 5 6 7 8 9 10 10 Save filename mxs 10 free parameters I 1 1 3 4 3 1 10 1 3 9 3 4 10 Get filename mxs back to 10 free parameters II 1 1 3 4 5 6 6 8 9 10 8 III 1 1 3 4 5 1 1 8 9 10 7 IV 1 1 3 4 3 1 1 8 9 8 5 V 1 1 3 4 3 1 1 3 9 3 4 Univariate Genetic Analysis n Saturated Models Free variances covariances Free means n Univariate Models Variances partitioned in a c d and e Free means or not 3 ACE Model 1 or 5 1 1 1 1 A 1 C a 1 E c E e 1 C e T1 c A a T2 ACE Model Means 1 or 5 1 1 1 A 1 1 C a c E 1 E e 1 C e T1 c A a T2 m1 or m3 m2 or m4 1 4 Tests ACE model n Is a significant CE model n Is c significant AE model n Is there significant family resemblance E model n n ADE model Estimate variance components ACED model OZ BMI data younger females n n n n n n n n n n n n n n n NGroups 4 define nvar 1 define nvar2 2 Title 1 Model Parameters Calculation Begin Matrices X Lower nvar nvar Free a Y Lower nvar nvar c Z Lower nvar nvar Free e W Lower nvar nvar Free d H Full 1



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