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Protein Tertiary Structure Prediction



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23 Protein Tertiary Structure Prediction 10 15 07 Required Reading BCB 444 544 before lecture Mon Oct 15 Lecture 23 Lecture 24 Protein Tertiary Structure Prediction Chp 15 pp 214 230 Protein Tertiary Structure Prediction Wed Oct 17 Thurs Oct 18 Lecture 24 Lab 8 Terribilini RNA Structure Function RNA Structure Prediction Chp 16 pp 231 242 Fri Oct 18 Lecture 25 24 Oct17 Gene Prediction Chp 8 pp 97 112 BCB 444 544 F07 ISU Terribilini 24 RNA Secondary Structure Prediction 10 17 07 1 New Reading Homework Assignment BCB 444 544 F07 ISU Terribilini 24 RNA Secondary Structure Prediction 10 17 07 2 Seminars this Week ALL HomeWork 4 emailed posted online Sat AM Due Mon Oct 22 by 5 PM not Fri Oct 19 BCB List of URLs for Seminars related to Bioinformatics http www bcb iastate edu seminars index html Read Oct 18 Thur BBMB Seminar 4 10 in 1414 MBB Sachdeve Sidhu Genentech Phage peptide and antibody Ginalski et al 2005 Practical Lessons from Protein Structure Prediction Nucleic Acids Res 33 1874 91 libraries in protein engineering and ligand selection http nar oxfordjournals org cgi content full 33 6 1874 PDF posted on website Although somewhat dated this paper provides a nice overview of protein structure prediction methods and evaluation of predicted structures Oct 19 Fri BCB Faculty Seminar 2 10 in 102 ScI Lyric Bartholomay Ent ISU TBA Your assignment is to write a summary of this paper for details see HW 4 posted online sent by email on Sat Oct 13 BCB 444 544 F07 ISU Terribilini 24 RNA Secondary Structure Prediction 10 17 07 3 Chp 15 Tertiary Structure Prediction SECTION V 10 17 07 4 Tertiary Structure Prediction Methods 2 or 3 Major Methods 1 Comparative Modeling Homology Modeling easiest Threading and Fold Recognition harder 2 Ab Initio Protein Structural Prediction really hard STRUCTURAL BIOINFORMATICS Xiong Chp 15 Protein Tertiary Structure Prediction BCB 444 544 F07 ISU Terribilini 24 RNA Secondary Structure Prediction Methods Homology Modeling Threading and Fold



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