BIOL 1361 1nd Edition Lecture 14Outline of Last Lecture I. Figure 4.17II. MitochondriaIII. Citric Acid CycleIV. Pyruvate OxidationV. CoAVI. Source of SubstratesVII. Electron TransportVIII. Electron Transport in Eukaryotic CellsOutline of Current Lecture I. ComplexesII. Role of O2III. H+ GradientIV. Chemiosmosis and Oxidative Phosphorylation V. ATP SynthaseVI. Cellular Respiration Interaction SummaryCurrent LectureI. ComplexesThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.a. Electron Transport Chain – complexes of proteins in the inner mitochondrial membrane that accept and donate electrons in a sequencei. Many of these proteins contain Feb. The sequence ends with O2 accepting electrons to become H2Oi. O2 is the final electron acceptorII. Role of O2a. The final acceptor of the electrons removed from chemical bonds during catabolism of biomoleculesb. 2H+ + 2e- + 1/2OC H2Oc. Reaction occurs in the mitochondrial matrixIII. H+ Gradienta. High [H+] in the Intermembrane spaceb. Drawing IV. Chemiosmosis and Oxidative Phosphorylation (Fig 17.3)a. Chemiosmosis - diffusion of H+ through ATP synthase in inner mitochondrial membraneb. Proton Motive Force i. Moves a rotor protein that is part of ATP synthaseii. Created by H+ gradient from Intermembrane space into matrixV. ATP Synthasea. Enzyme that catalyzes ADP + PO4 ATPb. Rate at which this happensi. 1 ATP forms for every 4 H+ that flow throughc. Scale at which this happensi. 1000s ATP synthase molecules per mitochondrionii. 1000s mitochondria per liver or muscle celliii. 10 x 10^6 ATP/second/muscle cellsVI. Cellular Respiration Interactive Summarya. Glycolysis in cytosol provides substrate for…i. Glucose pyruvateb. Citric Acid Cycle in mitochondrial matrixc. Provides electrons (via NADH and FADH2) to electron transport chain in mitochondrial inner membraned. Powers H+ movement into Intermembrane spacee. H+ flows back into matrix turning ATP synthasef. ATP produced in mitochondrial matrixg. ATP used in cytoplasm and plasma
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