DOC PREVIEW
UH KIN 3304 - The Lymphatic System

This preview shows page 1-2 out of 5 pages.

Save
View full document
View full document
Premium Document
Do you want full access? Go Premium and unlock all 5 pages.
Access to all documents
Download any document
Ad free experience
View full document
Premium Document
Do you want full access? Go Premium and unlock all 5 pages.
Access to all documents
Download any document
Ad free experience
Premium Document
Do you want full access? Go Premium and unlock all 5 pages.
Access to all documents
Download any document
Ad free experience

Unformatted text preview:

KIN 3304 1nd Edition Lecture 18Outline of Last Lecture I. Heart Releases HormonesII. Pancreatic IsletsIII. Regulating Bone GrowthIV. Vitamin DV. Parathyroid HormoneVI. CalcitoninVII. GH and T4VIII. Estrogen and TestosteroneIX. DisordersOutline of Current Lecture I. Lymphatic SystemII. Functions of Lymphoid SystemIII. ThymusIV. Other StufV. Functions of Lymphatic SystemVI. LymphedemaVII. Functions of Lymphatic System cont.VIII. Lymphatic CapillariesThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.IX. Lymphatic Collecting VesselsX. Deep LymphaticsXI. Figure 23.16XII. LymphomasXIII. Figure 23.4XIV. Thoracic DuctXV. LymphocytesXVI. Diferent Types of LymphocytesCurrent LectureI. Lymphatic Systema. Lymph nodes (LN) found throughout the bodyb. Easily palpable during infection, diseasec. Exercise helps immune systemd. Lymphatic vessels run parallel to blood vesselsII. Functions of Lymphoid Systema. Produce, maintain, distribute lymphocytes i. Produced within spleen, thymus, bone marrowii. Thymus, BM are 1 degree lymphoid organs1. Spleen is also 1 degree in mice2. T Cells originate in bone marrow and go to the thymus to get educatedIII. Thymusa. Gets smaller with ageb. Has blood-thymus barrieri. Similar to BBB; prevents leakage of cells c. 2 Thymic lobesi. Outer cortex, central medullaii. Cortex-lymphoid stem cells (rapidly dividing)1. Daughter cells move to medulla2. Highly selective (~2% survive selection)iii. Ventricular cells produce thymic hormones1. Promotes diferentiation of functional T cellsIV. Other Stufa. Thymic involutioni. Older = involutionii. Increases susceptibility to novel pathogens – why?b. Nudec. SCIDi. “bubble boy” – no protectionV. Functions of Lymphatic Systema. Maintain blood volume, chemistryi. BP at proximal end of systematic capillary ~35mm Hg1. Forces water/solutes into interstitial fluid2. Lymphoid System returns watera. (~3.6L/day) to bloodb. helps to put H20 back in blood supplyVI. Lymphedemaa. Lymphatic vessel blocked, compressed, of if valves are damagedb. Drainage slows/stops = swellingc. Wears a sleeve to pump fluidVII. Functions of Lymphatic System cont.a. Alternate route for hormones, nutrients, wastei. Immune cells, cytokines, etc.ii. Lipids carried to blood stream rather than capillariesVIII. Lymphatic Capillariesa. Complex network within peripheryi. Difer from vascular system:ii. Larger in diameteriii. Thinner walls (no continuous basal lamina)iv. Irregular outflowv. Anchoring filaments (keep open during increasing pressure)vi. Overlapping (not tightly banded) endothelial cells1. Acts as one-way valveIX. Lymphatic Collecting Vesselsa. Superficial lymphaticsi. Subcutaneous (sub-Q; next to skin)ii. Loose CT of mucus membranes1. Digestive, respiratory, urinary, reproductiveiii. Loose CT of serous membranes1. Pleural, pericardial, peritonealX. Deep Lymphatics a. Accompany deep arteries/veinsb. Collect lymph from smooth muscle, organsXI. Figure 23.16 (Know this)a. Cervical CN – head and neckb. Axillary LN – trunk from the upper limbsi. Female axillary nodes also drain from mammary glands c. Popliteal LN – thigh from the legi. Inguinal LN monitor lymph at the trunk from lower limbsd. Thoracic LN – lymph from the lungs, respiratory passageways, and mediastinal structurese. Abdominal LN – urinary and reproductive systemf. Peyer’s patches, intestinal LN, and the mesenterial LN receive lymph originating from the digestive tractsXII. Lymphomasa. Malignant tumorsi. Cancerous lymphocytes/lymphatic stem cellsii. 61,000 cases/year in US (very high in dogs)b. Hodgkin’s Diseasei. 1 of 7 lymphoma casesii. 15-35 or over 50 (unknown to why these ages)iii. Infectious agent (virus) probably involvedc. Non-Hodgkin’s lymphomal (NHL )i. Abnormalities in chromosomes (55% of cases) XIII. Figure 23.4a. Look at the type of drainageXIV. Thoracic Ducta. Collects lymph from here (look in the picture in 23.4)i. Cisterna chili receives lymph from inf. Abdomen, pelvis, lower limbs*too little of a response, pathogen wins*too large of a response, system kills hostXV. Lymphocytesa. Primary cells of the lymphoid systemi. Respective for specific immunityb. Respond to:i. Invading organism (bacteria, viruses)ii. Abnormal cells (cancer, virally-infected)iii. Foreign proteins, toxinsXVI. Diferent Types of Lymphocytesa. T Cells (thymus derived)i. Travel to thymus from BM; become educatedb. B Cells (Bursa if fabricus; BM derived)i. Developed in BM, travel to periphery, thymus, etc.c. NK Cells (natural killer)i. Seek out, destroy non-self


View Full Document

UH KIN 3304 - The Lymphatic System

Documents in this Course
The Cell

The Cell

23 pages

Load more
Download The Lymphatic System
Our administrator received your request to download this document. We will send you the file to your email shortly.
Loading Unlocking...
Login

Join to view The Lymphatic System and access 3M+ class-specific study document.

or
We will never post anything without your permission.
Don't have an account?
Sign Up

Join to view The Lymphatic System 2 2 and access 3M+ class-specific study document.

or

By creating an account you agree to our Privacy Policy and Terms Of Use

Already a member?