Welcome to General Principles and Concepts of Biology!Today’s Goals:Next Time…I. Cell DivisionSlide 5Slide 6Consider the pictures below. Which answer best describes the relationship between these objects?Slide 8PowerPoint PresentationSlide 10Slide 11Slide 12Slide 13Slide 14Slide 15Slide 16Slide 17Slide 18Slide 19Slide 20Slide 21Slide 22Slide 23Slide 24Slide 25Slide 26Slide 27Slide 28Slide 29In-class Project Get in groups of 2 Fill out a 4X6 cardSlide 31MitosisSlide 33Slide 34Slide 35Slide 36Slide 37Welcome to General Principles and Concepts of Biology!BioSci 1010, Sec. 2ANNOUNCEMENTS:Exam #1:Multiple choice scores posted (90 points)Post answer key todayAssignment-Science NewsPost todayMasteringBiologyNo recent grade updatesStudy AreaToday’s Goals:Readings: Chapter 6I. Cell DivisionA. What is cancer?B. Purpose of cell divisionC. Main stepsD. DNA replicationE. MitosisF. CytokinesisNext Time…Readings: Chapter 6I. Cell DivisionA. What is cancer?B. Purpose of cell divisionC. Main stepsD. DNA replicationE. MitosisF. CytokinesisG. Cell cycle: cancer short-circuitsII. MutationI. Cell Divisionhttp://www.cbs.dtu.dk/staff/dave/roanoke/genetics980218.htmlI. Cell Division1. What is a chromosome?a. Long molecule of DNA.b. DNA twisted around proteins called histones- 7,000,000  m DNA fits in 10 m!- 80 BILLION miles of DNA in you! 80,000,000,000 milesI. Cell Division1. What is a chromosome?a. Long molecule of DNA.b. Compacted around histones c. We have 46 chromosomes in every celli. 23 different typesii. Two of each typeHow do we get two of each type?Consider the pictures below. Which answer best describes the relationship between these objects?A B1.A and B are the same thing2.A is found in B3.B is found in A4.There is no relationshipConsider the pictures below. Which answer best describes the relationship between these objects?A B1.A and B are the same thing2.A is found in B3.B is found in A4.There is no relationshipATGTTCGTACAAGCTAATCGATATGCCGa. The strands separateD. DNA Replication2. Steps in DNA ReplicationATGTTCGTACAAGCTAATCGATATGCCGa. The strands separateD. DNA Replication2. Steps in DNA ReplicationATGTTCGTACAAGCTAATCGATATGCCGa. The strands separateb. Free nucleotides attach to the strandsD. DNA Replication4. Steps in DNA ReplicationATGTTCGTACAAGCTAATCGATATGCCGa. The strands separateb. Free nucleotides attach to the strandsD. DNA Replication2. Steps in DNA ReplicationATGTTCGTACAAGCTAATCGATATGCCGa. The strands separateb. Free nucleotides attach to the strandsD. DNA Replication2. Steps in DNA ReplicationATGTTCGTACAAGCTAATCGATATGCCGa. The strands separateb. Free nucleotides attach to the strandsD. DNA Replication2. Steps in DNA ReplicationATGTTCGTACAAGCTAATCGATATGCCGa. The strands separateb. Free nucleotides attach to the strandsD. DNA Replication2. Steps in DNA ReplicationATGTTCGTACAAGCTAATCGATATGCCGa. The strands separateb. Free nucleotides attach to the strandsD. DNA Replication2. Steps in DNA ReplicationATGTTCGTACAAGCTAATCGATATGCCGa. The strands separateb. Free nucleotides attach to the strandsD. DNA Replication2. Steps in DNA ReplicationATGTTCGTACAAGCTAATCGATATGCCGa. The strands separateb. Free nucleotides attach to the strandsD. DNA Replication2. Steps in DNA Replicationa. The strands separateb. DNA polymerase attaches free nucleotides to the strandsD. DNA Replication2. Steps in DNA Replication© 2013 Pearson Education, Inc.BioFlix: DNA Replication© 2013 Pearson Education, Inc.Before: Single long & tangled DNA moleculeAfter: Two condensed DNA molecules connected at centromereI. Cell DivisionD. DNA Replication5. Chromosome structure afterDNA replicationa. The two halves of the replicated chromosome are called sister chromatidsThe replicatedchromosomeI. Cell DivisionA chromatidD. DNA Replication5. Chromosome structure afterDNA replicationa. The two halves of the replicated chromosome are called sister chromatidsI. Cell DivisionD. DNA Replication5. Chromosome structure afterDNA replicationa. The two halves of the replicated chromosome are called sister chromatidsThe sister chromatidI. Cell DivisionD. DNA Replication5. Chromosome structure afterDNA replicationb. The chromatids are attached at the centromereThe centromereI. Cell DivisionD. DNA Replication5. Chromosome structure afterDNA replicationc. Occurs in homologous chromosomesHomologous chromosomesI. Cell DivisionAre the two homologous chromosomes the same?I. Cell DivisionSame genesDifferent versions of the genesIn-class ProjectGet in groups of 2 Fill out a 4X6 cardU2 IC1Name 1 Student #1 Signature 1Name 2 Student #2 Signature 21. Pretend that you are DNA polymerase: pair the correct nucleotides with this single strand of DNAA T C C G T T A C G2. Draw a cell with 2 types of chromosomes after DNA replication. Label: sister chromatid, centromere, homologous chromosomesI. Cell DivisionMain stepsD. DNA ReplicationE. Mitosis - division of the nucleusF. Cytokinesis - division of the rest of the cytoplasmMitosisMovie source: http://www.youtube.com/watch?v=nPG6480RQo0I. Cell DivisionE. Mitosis1. Mitosis = Division of the nucleus (not the whole cell!)I. Cell DivisionE. Mitosis 2. The story of mitosis:a. Prophase: i. Starts whenchromosomes condense (become visible).I. Cell DivisionE. Mitosis 2. The story of mitosis:a. Prophase: i. Chromosomes condenseii. Nuclear envelope breaks upI. Cell Division2. The story of mitosis:a. Prophase: ii. Nuclear envelope breaks upiii. The spindle starts to form - a network of proteins that directs movement of chromosomesI. Cell Division2. The story of mitosis:a. Prophase: ii. Nuclear envelope breaks upiii. The spindle starts to form - a network of proteins that directs movement of chromosomes- attach to chromosomes @ the