SyllabusFall 2004Course: Statistics 892, Statistical GenomicsInstructor: Steve KachmanOffice: 104 D Miller HallPhone: 472-7302Office Hours: I will generally be available in the afternoonPrerequisites: Basic StatisticsBasic BiologyHomework: Approximately once every other week20% will be deducted for each day late.Exams: Two exams, will be announced at least one week in advanceFinal Exam: Monday, December 13 10:00-NoonRevise travel plans accordingly.Conflicts: Expected to take exams at the scheduled timeIf an exam conflicts with an activity vital to your program,please have your major adviser contact me well in advance.I should be notified as soon as possible of any potential conflicts.Grading: Exams 200 ptsFinal 150 ptsHomework and Quizzes 100 ptsGrading will be on a straight 90, 80, 70, 60 percent basis.Available at http://blackboard.unl.edu/Web page: http://statistics.unl.edu/faculty/steve/statgen/2004/1Statistical genomics involves the integration of both statistics and genetics. As s uch, studentswill be expected to understand both biology and the statistics. As with many areas of science,teams which bring together people with different areas of expertise are the norm. This is theapproach we will take in this class.The objective of this course is to examine a variety of topics in the area of statistical genomics.Initially we will examine the design and analysis of cDNA microarray experiments. The specifictopics to be covered later in the course will depend on the specific areas of interest of students inthe class.Preliminary Topics• Basic Genetics• cDNA Microarrays– Introduction– Design– Normalization– Estimation and Testing∗ Linear Models∗ Bayesian models∗ False Discovery