BIO 151 1nd Edition Lecture 9 Outline of Last Lecture- Energy flow- Enzymes- Metabolic pathwayso Feedback inhibition- ATP- Mitochondria- Cellular Respirationo OverviewOutline of Current Lecture - Cellular Respirationo Overview - Glycolysis- Citric acid cycle- Role of NAD+- Oxidative phosphorylationo Electron transporto ATP synthesis via ChemosisCurrent LectureProcess Cellular Compartment Mechanism of ATP SynthesisGlycolysis Cytosol Substrate-level phosphorylationCitric acid cycle Mitochondrial matrix Substrate-level phosphorylationOxidative phosphorylation* Mitochondrial membrane (cristae)Chemiosmosis *Technically 2 separate reactions- Glycolysis: (splitting of glucose sugar)These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.o 6C 3C+3Co 1 glucose + 2ATP2pyruvate +4ATP net yield: 2ATP/Glucose Costs energy to start systemo Phase I: energy-investment phaseo Phase II: cysis phaseo Phase III: energy-recovery phase (x2)- Citric Acid Cycleo Citric Acid cycle (mitochondria) ATP yield: 28-30ATP/2pyruvates Total: 30-32 ATP/glucoseo Fermentation (cytosol) ATP yield: 0ATP/2pyruvate Total: 2ATP/glucoseo Citric acid cycle=kreb’s cycle=TCA cycle Fate of C skeleton- Feed in 2C as acetyl CoA- Lose 2C as CO2 ATP synthesis: 1 rxn where ATP is produced by substrate level phosphorylation- 1ATP/”turn” of cycle- per glucose: 2 pyruvate2acetyl CoAo 2 turns of cycle- total:2pyruvate: 2 ATP- REDOX REACTIONS: involve transfer of e- between 2 compounds; one acts as the e- donor and 1 acts as the e- acceptor; always look at reactants for answerso Cellular electron carriers: Most common: NAD+/NADH + H+ (nicotinamide adenine dinucleotideo 1 redox rxn in glycolysis calculated electrons:- glycolysis: 2 (NADH+ H+)- 3C2C: 2 (NADH+ H+)- Citric acid cycle: 6(NADH+ H+); 2
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