PSYCH 105 Lecture 5Outline of Current Lecture I. Clicker QuestionsII. Drugs Alter Synaptic TransmissionCurrent LectureI. Clicker Questions- What is serotonin responsible for?o Regulating emotions and appetite- What is dopamine responsible for?o Reward, motivation, movement- What is acetylcholine responsible for?o Controlling movementsII. Drug Alter Synaptic Transmission- Alcohol (ethyl alcohol or ethanol)o Binds to receptors for ACh, 5-HT, GABA, and glutamateo Initial increase in Serotonin and Norepinephrine transmissiono Sedative effects, lower inhibition, slower information processing, lower coordinationo Withdrawal symptoms can include tremors, sleep problems, depression,nausea, hallucinations, seizures, and death- Nicotineo Mimics acetylcholine and binds to nicotinic receptorso Excitation of neurono These excited neurons, in turn, release dopamine- Cocaineo Blocks reuptake of DA, ME, and 5-HTo Increased feeling of pleasure and increased movemento Withdrawal symptoms include fatigue, irritability, sleepiness- Cannabiso THC binds to same receptors as anandamide (endocannabinoids)o Slight euphoria, relaxation, amplified auditory and visual perceptions, analgesiao Increased DA releaseo Interactions with glucocorticoids (stress hormones) and endorphins- Opiates (prescription pain killers, heroin, morphine, etc.)These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.o Bind to opioid receptors (the same as endorphins)o Analgesia, euphoriao Increased GABA, increased DA releaseo Suppressed CNso Withdrawal symptoms include extreme pain, diarrhea, itching, nausea, sweating, tremors, weakness, depression, suicidal- Ecstasy (MDMA)o Increased release in 5-HTo Potentiates effects of NE and DAo Increased energy, euphoria, suppression, of inhibitions, feelings of intimacy and mild psychedelico After effects include anxiety, depression, fatigue, loss of appetite, aches,insomnia and dizziness- Benzodiazepines (Valium, Xanax, Klonopin)o Increase efficiency of synaptic transmission of GABAo Sedative, hypnotic (sleep inducing), anxiolytic (anti-anxiety), anticonvulsant, muscle relaxanto Withdrawal symptoms include, panic attacks, tremor, cognitive problems, headache, muscle pains, hallucinations, seizures,