PSYCH 265 1st Edition Lecture 11Outline of Last Lecture I. Pharmacodynamics II. Proteins a. Structural b. Transporterc. Enzymesd. Ion channelse. Receptors III. What do drugs do?IV. NeurotransmitterV. Receptor agonists VI. Receptor antagonists VII. Releasing agentsVIII. Reuptake inhibitors IX. Presynaptic regulation Outline of Current Lecture I. Dose response curveII. Log vs. linear scaleIII. Semi-log dose response curveThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.IV. Drug antagonisma. Chemical b. Physiological c. Pharmacological V. Competitive vs. noncompetitive antagonismCurrent Lecture-Dose response curveoIncreased amount of drug=increased effect of drugoIncreased dose=increased response till you hit a point the drug effect plateaus -Logarithmic vs. linear scaleoLog scale is nonlinear that is based on orders of magnitude instead of linear scaleoExamples of log scales include the Richter scale for earthquakes and the pH scale-Semi-log dose response curveoUsed for pharmacologyoS shapedoAll drugs will produce s shaped curve-Threshold, ED50 and ceiling oThreshold-->ED50---->ceiling -Full vs. partial agonistoFull-Drug that binds to receptors and cause maximal effectoPartial-Drug that does not have complete efficacy, binds to receptor but its max effect may only be 30%, 40% ect. Because it does not activate receptor fullyoInverse -FYI-Potency oDrug a & b-Drug antagonismoChemical antagonism -Antagonist drug binds to the agonist drug and prevents the agonist drug from interacting with its targetoPhysiological antagonist-Antagonist drug acts on a target that is independent of the target that is activated by the drug agonist-Effects of the 2 targets are in opposite directionsoPharmacological antagonism -Antagonist drug competes with the agonist drug for binding to the same target-Competitive vs. noncompetitive antagonism oCompetitive-Antagonist drug binds to same target receptor as the agonist drug in a reversiblemanneroNoncompetitive -Antagonist drug binds to same target receptor as the agonist drug in an irreversible manner-Effective vs. lethal
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