UW-Madison BIOLOGY 101 - Lysosomes, Evolution of Eukaryotic Cell, Endomembrane System (3 pages)

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Lysosomes, Evolution of Eukaryotic Cell, Endomembrane System



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Lysosomes, Evolution of Eukaryotic Cell, Endomembrane System

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Lecture number:
8
Pages:
3
Type:
Lecture Note
School:
University of Wisconsin, Madison
Course:
Biology 101 - Zoology 101: Animal Biology
Edition:
1
Documents in this Packet

Unformatted text preview:

Zoology101 Animal Biology Last Lecture Outline Lecture 8 1 Archaea 2 Eukaryotic Cells Animal Cell 3 Nuclear Components Nucleous Lamina 4 Protein sorting targeting 5 Intro to Endomembrane System Current Lecture 1 What Happens in the ER Process of protein 2 What happens in the Golgi 3 Lysosomes 4 Cytoskeleton 5 Peroxisomes 6 Mitochondria and chloroplast 7 Evolution of Eukaryotic Cell What Happens in the ER Steps of a protein Secreted proteins enter ER as they are being synthesized by ribosome Protein exists ER in a vesicle Bleb Protein travels through cisternae of Golgi Protein enters a secretory vesicle that fuses with cell membrane Protein is secreted from cell Protein folding with help of chaperones proteins that help other proteins fold Chemical modification glycosylation attachment of oligosaccharide made in rough ER glycoprotein Cleavage cutting of proteins What happens in the Golgi Further modification of proteins and lipids made by ER Glycosylation trimming Sorting station before molecules move to final destinations Carbohydrate synthesis Final destinations Secreted outside the cell exocytosis plasma membrane lysosome Lysosome Digestive compartment recycle center of cell contains hydrolytic enzymes pH 5 in order to breakdown molecules more acidic than cystol How Proton pump in lysosomal membrane increase H concentration Why Optimal pH for hydrolytic enzymes Products get transported after digestion lysosomes can fuse with endocytic vesicle phagocystosis Lysosomes can digest materials in cell autophagy Lysosomal storage diseases Pompe s disease Defect in enzyme gylcogen build up in muscle liver cells organs destroyed Proteins localized in ER by cellular zipcode signal peptide Soluble protein with signal peptide and no other zipcode excreted from cell Membrane protein with signal peptide and no other zip code plasma membrane Proteins that need to stay in ER have signal peptide and another zipcode ER retention signal Lysosomal proteins have signal peptide and zip



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