19. Systemic Lupus Erythematosis Learning Objectives and SummaryLecture 19. Systemic Lupus Erythematosis Learning Objectives 1. To understand proposed mechanisms for the development and progression of autoimmune diseases 2. To review clinical manifestations of SLE and understand how pathogenic autoantibodies might lead to their emergence. 3. To understand some of the environmental triggers and non-genetic components of SLE Summary 1. Immune complexes can be pro-inflammatory. 2. Autoimmune disease requires genetic and non-genetic triggers. 3. Molecular mimicry leads to autoreactivity. 4. Autoreactivity is normal (when it does not lead to organ
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