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19 Systemic Lupus Erythematosis Learning Objectives and Summary Lecture 19 Systemic Lupus Erythematosis Learning Objectives 1 2 3 To understand proposed mechanisms for the development and progression of autoimmune diseases To review clinical manifestations of SLE and understand how pathogenic autoantibodies might lead to their emergence To understand some of the environmental triggers and non genetic components of SLE Summary 1 Immune complexes can be pro inflammatory 2 Autoimmune disease requires genetic and non genetic triggers 3 Molecular mimicry leads to autoreactivity 4 Autoreactivity is normal when it does not lead to organ damage



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