LEHIGH BIOS 328 - IMMUNOLOGY (13 pages)

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IMMUNOLOGY



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IMMUNOLOGY

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Pages:
13
School:
Lehigh University
Course:
Bios 328 - Immunology
Immunology Documents

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IMMUNOLOGY Bios 328 a textbook based study of immunology Spring 2003 http www lehigh edu sk08 Courses Bios328 mainpage htm Review Initial differentiation s thymic maturation Initial differentiation c Kit receptor for stem cell growth factor CD44 an adhesion molecule CD25 chain of IL 2 receptor Fundamental notion Positive selection of thymocytes bearing receptors capable of binding self MHC molecules which results in MHC restriction Negative selection by elimination of thymocytes bearing highaffinity receptors for self MHC molecules alone or self antigen presented by self MHC which results in self tolerance Another fundamental notion There are first double negatives DN s Then there are double positives DP s DN and DP refer to the presence of CD4 and CD8 The effect Note what s happening and where Evidence for Positive selection Negative selection Activation in the periphery some key events Overview Some common themes in signal transduction The involvement of receptors The generation of second messengers The action of protein kinases and phosphatases The induced assembly of critical components of a signal transduction pathway Cascades The involvement of large and small G proteins The default setting for signal transduction is OFF The co stimulatory signal Co Stimulatory Differences among Antigen Presenting Cells APC s



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