BMS 300 1st edition Lecture 14Outline of Last LectureI. Cells of mesenchymal origin -fibrocytes 1. CTP (connective tissue paper) -chondrocytes 1. cartilage -osteocytes (secrete calcium phosphate) 1. bone -hematopoietic stem cell 1. blood II. Extracellular proteins of connective tissue -collagenrope like -elastinstretchy -glycosaminoglycanglass and epoxy like III. Skin as an organ -epithelium 1. epidermis -connective tissue proper 1. dermis These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.IV. Organization of epidermis -stratified squamous epithelium -keratinocytes -melanocytes V. Organization of the dermis -CTP1. fibrocytes 2. extracellular proteins Outline of Current Lecture VI. Appendages of Skin -exocrine glands -hair-nails/hooves VII. Bone Structure -bone is an organ -long bone structure 1. diaphysis—compact bone osteons 2. epiphysis—spongy bone trabecular bone -osteon structure 1. oskocytes >collagen: resist sheer forces >hydroxyapatite: resist to compression-bone growth 1. chondrocytes at the growth plate 2. growth plate closure -bone remodeling 1. osteoclasts: breaker 2. osteocytes: maker 3. parathyroid hormone central VIII. The endocrine system -requirements 1. sender: hormone releasing cell 2. messenger: hormone 3. receiver: hormone specific receptor Current LectureBone Structure (long bones)-those bones that are long in shape -femur, radius, ulna, phalanges -mostly contains calcium phosphate -heavy structure -we have a hollow part of the bone called the medullary cavity -bear weight/attach muscle -parts of the bone include: >hyaline cartilage: articular surface of the bone>periosteum: connective tissue proper (where the tendons and ligaments attach)>meniscus >epiphysis>diaphysis>medullary cavity: fat, yellow marrow >spongy bone: trabecular “struts” >compact bone -we bear force and weight through the spongy boneCompact Bone-organized into osteons Osteon: the organizing structure of compact bone >2-3 mm diameter >contains many osteocytes >the osteocytes are organized into concentric rings >the amount of oxygen of the bone determines the diameter -osteocytes will secrete collagen -the osteocytes are stacked and filled with collagen to form the bone which gives us laid out columns of calcium phosphate to help resist force -growth occurs between the diaphysis and the epiphysis -throughout our lives bones are changing Osteocytes: filled with hydroxyapatite which is growth plate closure and ends the increase in growth Bone Remodeling-osteoclasts: bone breakers—as we get older the osteoclasts get the upper hand>they settle on the bone, make a “dam” type structure which then mobilizes vesicles -osteocytes: bone
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