UCSD COGS 107B - ORGANIZATION OF MEMORY TRACES IN THE MAMMALIAN BRAIN (17 pages)

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ORGANIZATION OF MEMORY TRACES IN THE MAMMALIAN BRAIN



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ORGANIZATION OF MEMORY TRACES IN THE MAMMALIAN BRAIN

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Pages:
17
School:
University of California, San Diego
Course:
Cogs 107b - Systems Neuroscience
Systems Neuroscience Documents

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Annual Reviews www annualreviews org aronline Annual Reviews www annualreviews org aronline 520 THOMPSON KRUPA ORGANIZATION OF MEMORY TRACES IN THE MAMMALIAN BRAIN Richard F Thompson and David J Krupa Programfor Neural Informational and BehavioralScience Universityof Southern Califomia Los Angeles Califomia90089 2520 KEYWORDS cerebellum learningandmemory eyeblinkconditioning memory localization classicalconditioning INTRODUCTION Perhaps the most fundamentalissue in the broad field of neuronal substrates of learning and memoryconcerns the physical biological mechanismsunderlying long term memoryformation storage and retrieval in the mammalian brain Considerable progress has been made in elucidating memorystorage mechanismsin simpler invertebrate systems Abramset al 1991 Bergold et al 1990 Clark Schuman1991 Crow Forrester 1990 Nelson Alkon 1990 but similar advances have yet to be made in understanding the mammalianbrain As Lashley 1929 stressed so many years ago the overriding problem for understanding memorymechanismsin the mammalian brain is localization of memorystorage Mechanismsof memorystorage cannot be analyzed until the memorystorage sites whether localized or distributed have been identified Giventhe nature of the vertebrate brain memoriesshould to somedegree be distributed over ensemblesof neurons but whetherthis is within a localized region over several regions in a given structure or over several structures is not yet knownfor most forms of memory Oncethe locus or loci of a given form of long term memoryhas been determined we should be able to analyze the mechanismsof memorystorage Thesewill likely involve chemical structural changesat synapses and possibly long lasting changes in gene expression in the relevant neurons Determining these mechanisms however will not inform us of what the memoryis the 519 Annu Rev Neurosci 1994 17 519 549 Downloaded from arjournals annualreviews org by University of California San Diego on 01 05 07 For personal use only Annu



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