View Full Document

12 views

Unformatted text preview:

Carbohydrates III Lipids I Andy Howard Introductory Biochemistry Fall 2010 21 September 2010 As delivered by Nick Menhart Biochem Carbo III Lipids I 09 21 2010 Sugar Complexes and Lipids Sugars form complexes with proteins and lipids Lipids are critical as energy storage molecules and as components of membranes 09 21 2010 Biochem Carbo III Lipids I p 2 of 50 Plans for Today Glycoconjugates Proteoglycans Peptidoglycans Glycoproteins Lipids Classes of lipids Fatty acids Triacylglycerols 09 21 2010 Lipids continued Glycerophospholipids Plasmalogens Sphingolipids Isoprenoids Steroids Other lipids Biochem Carbo III Lipids I p 3 of 50 Glycoconjugates Poly or oligosaccharides covalently linked to proteins or peptides Generally heteroglycans Categories Image courtesy Benzon Symposia Proteoglycans protein glycosaminoglycans Peptidoglycans peptide polysaccharide Glycoproteins protein oligosaccharide 09 21 2010 Biochem Carbo III Lipids I p 4 of 50 Proteoglycans Glycosaminoglycans Unbranched heteroglycans of repeating disaccharides One component is GalN GlcN GalNAc or GlcNAc Other component an alduronic acid OH or NH2 often sulfated Found in cartilage joint fluid 09 21 2010 Biochem Carbo III Lipids I p 5 of 50 Proteoglycans in cartilage Highly hydrated voluminous Mesh structure fig 7 36 or this fig from Mathews Van Holde Aggrecan is major proteoglycan Typical of proteoglycans in that it s extracellular 09 21 2010 Biochem Carbo III Lipids I p 6 of 50 Peptidoglycans G G fig 7 29 Polysaccharides linked to small proteins Featured in bacterial cell walls alternating GlcNAc MurNAc linked with 1 4 linkages Lysozyme hydrolyzes these polysaccharides Peptide is species specific often contains D amino acids 09 21 2010 Biochem Carbo III Lipids I p 7 of 50 Peptidoglycans in bacteria Gram negative thin peptidoglycan layer separates two phospholipid bilayer membranes Gram positive only one bilayer with thicker peptidoglycan cell wall outside it Gram stain binds to thick wall not thin layer



Access the best Study Guides, Lecture Notes and Practice Exams

Loading Unlocking...
Login

Join to view Carbohydrates III; Lipids I and access 3M+ class-specific study document.

or
We will never post anything without your permission.
Don't have an account?
Sign Up

Join to view Carbohydrates III; Lipids I and access 3M+ class-specific study document.

or

By creating an account you agree to our Privacy Policy and Terms Of Use

Already a member?