# MIT 6 021J - Lecture notes (4 pages)

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## Lecture notes

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## Lecture notes

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4
School:
Massachusetts Institute of Technology
Course:
6 021j - Quantitative Physiology: Cells and Tissues
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Quantitative Physiology Cells and Tissues 2 791J 2 794J 6 021J 6 521J BE 370J BE 470J HST 541J Recitation 14 November 2 2006 Austin Che Problem 4 12 A propagated action potential is recorded at one position along an axon Five points in time during this action potential are identified in Figure 1 Vm t t0 t4 t1 t t3 t2 Figure 1 Propagated action potential At t0 the membrane is in its resting state i e Vm t0 Vmo At t1 the membrane potential has a point of inflection i e 2 Vm t2 t1 0 At t2 the membrane potential is zero i e Vm t2 0 At t3 the membrane potential has its maximum value At t4 the membrane potential has its minimum value 1 t0 t1 t2 t3 t4 a b c d e f g h i j k None Table 1 Organization for answers to Problem 4 12 For each of the times t0 t1 t2 t3 and t4 determine which if any of the following statements apply in a precise manner If none applies precisely then indicate none Indicate your answers with a check mark in the appropriate places in a table such as Table 2 a The sodium conductance equals the potassium conductance b The membrane current is zero and changes from inward to outward c The membrane current is zero and changes from outward to inward d The capacitance current is zero e The total ionic current is zero f The sodium conductance has a maximum value g The potassium conductance has a maximum value h The sodium conductance has a minimum value i The potassium conductance has a minimum value j The magnitude of the potential difference between the membrane potential and the sodium equilibrium potential is a minimum k The magnitude of the potential difference between the membrane potential and the potassium equilibrium potential is a minimum 2 Problem 4 28 Each of the panels in Figure 2 shows action potentials computed from the HodgkinHuxley model of a space clamped axon in response to a current pulse of duration 0 5 ms and of amplitude 20 A cm2 In each panel the dashed curve shows the response for the standard 60 60 a 20 0 20 40 60 80 b 40 Membrane

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