View Full Document

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue



View the full content.
View Full Document
View Full Document

7 views

Unformatted text preview:

REPORTS 52 J Kaas C E Collins Curr Opin Neurobiol 11 498 2001 53 H Kosaki T Hashikawa J He E G Jones J Comp Neurol 386 304 1997 54 We thank S Ghaznavi and H J Alitto for their assistance with the animals and L Ungerleider National Institute of Mental Health NIMH and NIH and J Rauschecker Georgetown University for their critical reading of the manuscript and helpful sugges Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue Matthias Blu her 1 Barbara B Kahn 2 C Ronald Kahn1 Caloric restriction has been shown to increase longevity in organisms ranging from yeast to mammals In some organisms this has been associated with a decreased fat mass and alterations in insulin insulin like growth factor 1 IGF 1 pathways To further explore these associations with enhanced longevity we studied mice with a fat speci c insulin receptor knockout FIRKO These animals have reduced fat mass and are protected against age related obesity and its subsequent metabolic abnormalities although their food intake is normal Both male and female FIRKO mice were found to have an increase in mean life span of 134 days 18 with parallel increases in median and maximum life spans Thus a reduction of fat mass without caloric restriction can be associated with increased longevity in mice possibly through effects on insulin signaling 1 Joslin Diabetes Center and Department of Medicine Harvard Medical School One Joslin Place Boston MA 02215 USA 2Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston MA 02215 USA To whom correspondence should be addressed Email c ronald kahn joslin harvard edu 572 mice which were indistinguishable with regard to physiologic and metabolic parameters and have the same mixed genetic background as the FIRKO mice For the aging experi Supporting Online Material www sciencemag org cgi content full 299 5606 568 DC1 Materials and Methods Fig S1 30 September 2002 accepted 4 December 2002 ments 250 animals were housed under



Access the best Study Guides, Lecture Notes and Practice Exams

Loading Unlocking...
Login

Join to view Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue and access 3M+ class-specific study document.

or
We will never post anything without your permission.
Don't have an account?
Sign Up

Join to view Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue and access 3M+ class-specific study document.

or

By creating an account you agree to our Privacy Policy and Terms Of Use

Already a member?